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Abstract
<p class="first" id="P1">Age-associated changes to the mammalian DNA methylome are
well documented and thought
to promote diseases of aging, such as cancer. Recent studies have identified collections
of individual methylation sites whose aggregate methylation status measures chronological
age, referred to as the DNA methylation clock. DNA methylation may also have value
as a biomarker of healthy versus unhealthy aging and disease risk; in other words,
a biological clock. Here we consider the relationship between the chronological and
biological clocks, their underlying mechanisms, potential consequences, and their
utility as biomarkers and as targets for intervention to promote healthy aging and
longevity.
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