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      DNA Methylation Clocks in Aging: Categories, Causes, and Consequences

      , , , , ,
      Molecular Cell
      Elsevier BV

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          Abstract

          <p class="first" id="P1">Age-associated changes to the mammalian DNA methylome are well documented and thought to promote diseases of aging, such as cancer. Recent studies have identified collections of individual methylation sites whose aggregate methylation status measures chronological age, referred to as the DNA methylation clock. DNA methylation may also have value as a biomarker of healthy versus unhealthy aging and disease risk; in other words, a biological clock. Here we consider the relationship between the chronological and biological clocks, their underlying mechanisms, potential consequences, and their utility as biomarkers and as targets for intervention to promote healthy aging and longevity. </p>

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          Author and article information

          Journal
          Molecular Cell
          Molecular Cell
          Elsevier BV
          10972765
          September 2018
          September 2018
          : 71
          : 6
          : 882-895
          Article
          10.1016/j.molcel.2018.08.008
          6520108
          30241605
          7f54acb4-9ace-4b9d-853b-6b129a11a745
          © 2018

          https://www.elsevier.com/tdm/userlicense/1.0/

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