61
views
0
recommends
+1 Recommend
0 collections
    0
    shares
      • Record: found
      • Abstract: found
      • Article: found
      Is Open Access

      Imaging suicidal thoughts and behaviors: a comprehensive review of 2 decades of neuroimaging studies

      review-article

      Read this article at

      Bookmark
          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          Identifying brain alterations that contribute to suicidal thoughts and behaviors (STBs) are important to develop more targeted and effective strategies to prevent suicide. In the last decade, and especially in the last 5 years, there has been exponential growth in the number of neuroimaging studies reporting structural and functional brain circuitry correlates of STBs. Within this narrative review, we conducted a comprehensive review of neuroimaging studies of STBs published to date and summarize the progress achieved on elucidating neurobiological substrates of STBs, with a focus on converging findings across studies. We review neuroimaging evidence across differing mental disorders for structural, functional, and molecular alterations in association with STBs, which converges particularly in regions of brain systems that subserve emotion and impulse regulation including the ventral prefrontal cortex (VPFC) and dorsal PFC (DPFC), insula and their mesial temporal, striatal and posterior connection sites, as well as in the connections between these brain areas. The reviewed literature suggests that impairments in medial and lateral VPFC regions and their connections may be important in the excessive negative and blunted positive internal states that can stimulate suicidal ideation, and that impairments in a DPFC and inferior frontal gyrus (IFG) system may be important in suicide attempt behaviors. A combination of VPFC and DPFC system disturbances may lead to very high risk circumstances in which suicidal ideation is converted to lethal actions via decreased top-down inhibition of behavior and/or maladaptive, inflexible decision-making and planning. The dorsal anterior cingulate cortex and insula may play important roles in switching between these VPFC and DPFC systems, which may contribute to the transition from suicide thoughts to behaviors. Future neuroimaging research of larger sample sizes, including global efforts, longitudinal designs, and careful consideration of developmental stages, and sex and gender, will facilitate more effectively targeted preventions and interventions to reduce loss of life to suicide.

          Related collections

          Most cited references182

          • Record: found
          • Abstract: found
          • Article: not found

          Empathy for pain involves the affective but not sensory components of pain.

          Our ability to have an experience of another's pain is characteristic of empathy. Using functional imaging, we assessed brain activity while volunteers experienced a painful stimulus and compared it to that elicited when they observed a signal indicating that their loved one--present in the same room--was receiving a similar pain stimulus. Bilateral anterior insula (AI), rostral anterior cingulate cortex (ACC), brainstem, and cerebellum were activated when subjects received pain and also by a signal that a loved one experienced pain. AI and ACC activation correlated with individual empathy scores. Activity in the posterior insula/secondary somatosensory cortex, the sensorimotor cortex (SI/MI), and the caudal ACC was specific to receiving pain. Thus, a neural response in AI and rostral ACC, activated in common for "self" and "other" conditions, suggests that the neural substrate for empathic experience does not involve the entire "pain matrix." We conclude that only that part of the pain network associated with its affective qualities, but not its sensory qualities, mediates empathy.
            Bookmark
            • Record: found
            • Abstract: found
            • Article: not found

            Interoception: the sense of the physiological condition of the body.

            Converging evidence indicates that primates have a distinct cortical image of homeostatic afferent activity that reflects all aspects of the physiological condition of all tissues of the body. This interoceptive system, associated with autonomic motor control, is distinct from the exteroceptive system (cutaneous mechanoreception and proprioception) that guides somatic motor activity. The primary interoceptive representation in the dorsal posterior insula engenders distinct highly resolved feelings from the body that include pain, temperature, itch, sensual touch, muscular and visceral sensations, vasomotor activity, hunger, thirst, and 'air hunger'. In humans, a meta-representation of the primary interoceptive activity is engendered in the right anterior insula, which seems to provide the basis for the subjective image of the material self as a feeling (sentient) entity, that is, emotional awareness.
              Bookmark
              • Record: found
              • Abstract: not found
              • Article: not found

              The distributed human neural system for face perception

                Bookmark

                Author and article information

                Contributors
                +203-785-6180 , hilary.blumberg@yale.edu
                Journal
                Mol Psychiatry
                Mol. Psychiatry
                Molecular Psychiatry
                Nature Publishing Group UK (London )
                1359-4184
                1476-5578
                2 December 2019
                2 December 2019
                2020
                : 25
                : 2
                : 408-427
                Affiliations
                [1 ]GRID grid.488501.0, Orygen, The National Centre of Excellence in Youth Mental Health, ; Parkville, VIC Australia
                [2 ]ISNI 0000 0001 2179 088X, GRID grid.1008.9, Centre for Youth Mental Health, , The University of Melbourne, ; Parkville, VIC Australia
                [3 ]ISNI 0000000121885934, GRID grid.5335.0, Department of Psychiatry, University of Cambridge, ; Cambridge, UK
                [4 ]ISNI 0000000121548364, GRID grid.55460.32, Psychiatry, Dell Medical School, , University of Texas, ; Austin, TX USA
                [5 ]ISNI 0000000419368710, GRID grid.47100.32, Psychiatry, , Yale School of Medicine, ; New Haven, CT USA
                [6 ]Department of Veterans Affairs National Center for PTSD, Clinical Neurosciences Division, West Haven, CT USA
                [7 ]ISNI 0000000419368710, GRID grid.47100.32, Psychiatry and Women’s Health Research at Yale, , Yale School of Medicine, ; New Haven, CT USA
                [8 ]ISNI 0000000419368710, GRID grid.47100.32, Psychiatry, Radiology and Biomedical Imaging, Child Study Center, , Yale School of Medicine, ; New Haven, CT USA
                Author information
                http://orcid.org/0000-0003-1108-2921
                Article
                587
                10.1038/s41380-019-0587-x
                6974434
                31787757
                7f59db54-d650-4291-8248-1e2a6fbe6587
                © The Author(s) 2019

                Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

                History
                : 20 December 2018
                : 21 October 2019
                : 29 October 2019
                Funding
                Funded by: FundRef https://doi.org/10.13039/100000025, U.S. Department of Health & Human Services | NIH | National Institute of Mental Health (NIMH);
                Award ID: RC1MH088366, R01MH113230, R61MH111929
                Award ID: R01MH117601
                Award Recipient :
                Funded by: FundRef https://doi.org/10.13039/100001455, American Foundation for Suicide Prevention (AFSP);
                Funded by: FundRef https://doi.org/10.13039/100000874, Brain and Behavior Research Foundation (Brain & Behavior Research Foundation);
                Funded by: MQ Brighter Futures Award MQBFC/2, International Bipolar Foundation, For the Love of Travis Foundation, Women's Health Research at Yale, John and Hope Furth Endowment
                Funded by: U.S. Department of Health & Human Services | NIH | National Institute of Mental Health (NIMH)
                Funded by: FundRef https://doi.org/10.13039/501100000288, Royal Society;
                Award ID: Dorothy Hodgkin Fellowship DH15017
                Award Recipient :
                Funded by: Brain and Behavior Research Foundation (Brain & Behavior Research Foundation)
                Funded by: FundRef https://doi.org/10.13039/100000938, Robert E. Leet and Clara Guthrie Patterson Trust (Robert E. Leet & Clara Guthrie Patterson Trust);
                Funded by: FundRef https://doi.org/10.13039/100000738, U.S. Department of Veterans Affairs (Department of Veterans Affairs);
                Categories
                Expert Review
                Custom metadata
                © Springer Nature Limited 2020

                Molecular medicine
                neuroscience,predictive markers
                Molecular medicine
                neuroscience, predictive markers

                Comments

                Comment on this article