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      Involvement of mitochondrial apoptotic pathway and MAPKs/NF-κB inflammatory pathway in the neuroprotective effect of atractylenolide III in corticosterone-induced PC12 cells

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          Abstract

          Atractylenolide III (ATL-III), a sesquiterpene compound isolated from Rhizoma Atractylodis Macrocephalae, has revealed a number of pharmacological properties including anti-inflammatory, anti-cancer activity, and neuroprotective effect. This study aimed to evaluate the cytoprotective efficiency and potential mechanisms of ATL-III on corticosterone injured rat phaeochromo-cytoma (PC12) cells. Our results demonstrate that ATL-III increases cell viability and reduces the release of lactate dehydrogenase (LDH). The results suggest that ATL-III protects PC12 cells from corticosterone-induced injury by inhibiting the intracellular Ca 2+ overloading, inhibiting the mitochondrial apoptotic pathway and modulating the MAPK/NF- κB inflammatory pathways. These findings provide a novel insight into the molecular mechanism by which ATL-III protected the PC12 cells against corticosterone-induced injury for the first time. Our results provide the evidence that ATL-III may serve as a therapeutic agent in the treatment of depression.

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          Author and article information

          Journal
          CJNM
          Chinese Journal of Natural Medicines
          Elsevier
          1875-5364
          20 April 2018
          : 17
          : 4
          : 264-274
          Affiliations
          1 Modern Research Center for Traditional Chinese Medicine, Shanxi University, Taiyuan 030006, China
          2 Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, China
          Author notes
          *Corresponding author: ZHOU Yu-Zhi, Tel/Fax: 86-351-7011202, E-mail: zhou-yuzhi@ 123456sxu.edu.cn ; QIN Xue-Mei, qinxm@ 123456sxu.edu.cn

          These authors have no conflict of interest to declare.

          Article
          S1875-5364(19)30030-5
          10.1016/S1875-5364(19)30030-5
          31076130
          Copyright © 2019 China Pharmaceutical University. Published by Elsevier B.V. All rights reserved.
          Funding
          Funded by: National Nature Science Foundation of China
          Award ID: 81673572
          Funded by: Applied basic research project of Shanxi Province
          Award ID: 201601D021164
          Funded by: Innovation project of higher education institutions in Shanxi Province
          Award ID: 2016120
          Funded by: Construction of the Science and Technology Basic Condition Platform of Shanxi Province
          Award ID: 2014091022
          Funded by: rogram of Science and Technology of Shanxi Province
          Award ID: 20140313008-14
          This work was supported by the National Nature Science Foundation of China (No. 81673572), the Applied basic research project of Shanxi Province (No. 201601D021164), the Innovation project of higher education institutions in Shanxi Province (No. 2016120), the Construction of the Science and Technology Basic Condition Platform of Shanxi Province (No. 2014091022), and the Program of Science and Technology of Shanxi Province (No. 20140313008-14).

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