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      Potentiometric determination of captopril in pharmaceutical formulations Translated title: Determinação potenciométrica de captopril em formulações farmacêuticas

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          Abstract

          A simple, precise, rapid and low-cost potentiometric method for captopril determination in pure form and in pharmaceutical preparations is proposed. Captopril present in tablets containing known quantity of drug was potentiometrically titrated in aqueous solution with NaOH using a glass pH electrode, coupled to an autotitrator. No interferences were observed in the presence of common components of the tablets as lactose, microcrystalline cellulose, croscarmellose sodium, starch and magnesium stearate. The analytical results obtained by applying the proposed method compared very favorably with those obtained by the United States Pharmacopoeia Standard procedure. Recovery of captopril from various tablet dosage formulations range from 98.0 to 102.0%.

          Translated abstract

          Um método potenciométrico simples, preciso, rápido e de baixo custo foi proposto para a determinação de captopril na forma pura e em formulações farmacêuticas. O captopril presente em comprimidos em uma quantidade conhecida foi potenciometricamente titulado em meio aquoso com um titulador automático, empregando-se como titulante uma solução aquosa de NaOH e um eletrodo combinado de vidro sensível a pH. Interferências não foram observadas na presença de componentes comumente encontrados nos comprimidos, tais como, lactose, celulose microcristalina, croscarmelose sódica, amido e estearato de magnésio. Os resultados analíticos obtidos a partir da aplicação do método proposto estão em muito boa concordância com aqueles obtidos pelo método oficial descrito na Farmacopéia Americana. O recobrimento obtido para o captopril a partir de um estudo realizado com várias formulações farmacêuticas variou de 98.0 a 102.0%.

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          Most cited references28

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          Treatment of chronic congestive heart failure with captopril, an oral inhibitor of angiotensin-converting enzyme.

          The renin-angiotensin system is thought to maintain elevated systemic vascular resistance in heart failure. The hemodynamic effects of captopril (SQ 14225), an oral inhibitor of angiotensin-converting enzyme, were measured in 10 patients with stable congestive heart failure poorly controlled by digitalis and diuretics. At single daily doses of 25 to 150 mg, the cardiac index rose from 1.75 +/- 0.18 to 2.27 +/- 0.39 (mean +/- S.D.) liters per minute per square meter (P less than 0.001), and pulmonary-wedge pressure fell from 26.5 +/- 7.5 to 17.3 +/- 6.1 mm Hg (P less than 0.01). Systemic vascular resistance decreased from 2006 +/- 300 to 1393 +/- 238 dyne seconds per centimeter (P less than 0.001), and mean arterial pressure fell from 83.7 +/- 7.0 to 70.3 +/- 9.9 mm Hg (P less than 0.001) (mean +/- S.D.). Heart rate did not change appreciably. Hemodynamic alterations peaked at 90 minutes and persisted for three to four hours. Control plasma renin activity ranged from 1.1 to 7.3 ng per milliliter per hour and did not correlate with changes in hemodynamic values. Three patients on long-term treatment maintained clinical improvement. Although its mechanism of action has not been completely elucidated, captopril may prove useful in the treatment of chronic congestive heart failure.
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            Determination of pharmaceutical thiols by liquid chromatography with electrochemical detection: Use of an electrode with a conductive carbon cement matrix, chemically modified with cobalt phthalocyanine

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              Determination of captopril and its degradation products by capillary electrophoresis

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                Author and article information

                Journal
                eq
                Eclética Química
                Eclet. Quím.
                Fundação Editora da Universidade Estadual Paulista Júlio de Mesquita Filho - UNESP (São Paulo, SP, Brazil )
                0100-4670
                1678-4618
                2003
                : 28
                : 1
                : 39-44
                Affiliations
                [02] Araraquara SP orgnameUNESP orgdiv1Instituto de Química orgdiv2Departamento de Química Orgânica Brasil
                [01] Araraquara SP orgnameUNESP orgdiv1Instituto de Química orgdiv2Departamento de Química Analítica Brasil
                Article
                S0100-46702003000100005 S0100-4670(03)02800105
                10.1590/S0100-46702003000100005
                7f6ab845-a190-40a6-9508-34282d700637

                This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

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                Page count
                Figures: 0, Tables: 0, Equations: 0, References: 28, Pages: 6
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                SciELO Brazil


                pharmaceutical formulations,formulações farmacêuticas,captopril,determinação potenciométrica,potentiometric determination

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