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Posttranscriptional regulation of p53 and its targets by RNA-binding proteins.

Current Molecular Medicine

metabolism, Tumor Suppressor Protein p53, Transcriptional Activation, RNA-Binding Proteins, genetics, RNA, Neoplasm, RNA, Messenger, RNA Processing, Post-Transcriptional, Proto-Oncogene Proteins c-mdm2, Nuclear Proteins, Neoplasms, Humans, Genes, p53, Cyclin-Dependent Kinase Inhibitor p21, Cell Cycle Proteins

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      p53 tumor suppressor plays a pivotal role in maintaining genomic integrity and preventing cancer development. The importance of p53 in tumor suppression is illustrated by the observation that about 50% human tumor cells have a dysfunctional p53 pathway. Although it has been well accepted that the activity of p53 is mainly controlled through post-translational modifications, recent studies have revealed that posttranscriptional regulations of p53 by various RNA-binding proteins also play a crucial role in modulating p53 activity and its downstream targets.

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