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      14, 15-Epoxyeicosatrienoic acid promotes endothelial cell dependent adhesion of human monocytic tumor U937 cells.

      Biochemical and Biophysical Research Communications
      8,11,14-Eicosatrienoic Acid, analogs & derivatives, pharmacology, Cell Adhesion, drug effects, Cells, Cultured, Chromatography, High Pressure Liquid, Endothelium, cytology, enzymology, Fatty Acids, Unsaturated, Fluorescent Dyes, Humans, L-Lactate Dehydrogenase, metabolism, Prostaglandins, analysis, Thrombin, Tumor Cells, Cultured

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          Abstract

          Arachidonic acid (AA) can be metabolized in endothelial cells (EC) to a series of epoxides via cytochrome P-450 epoxygenase with 14,15 epoxyeicosatrienoic acid (14,15-EET) as the major product. In this communication we report that 14,15-EET significantly enhances U937 cell attachment to EC with maximal cell attachment at 2.5 to 5 x 10(-7) M 14,15-EET. Thus, 14,15-EET may play a substantial role in inflammation and/or atherogenesis by inducing monocyte attachment to EC.

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