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      Chemical constituents from Gnaphalium affine and their xanthine oxidase inhibitory activity

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          Abstract

          Gnaphalium affine D. Don, a medicinal and edible plant, has been used to treat gout in traditional Chinese medicine and popularly consumed in China for a long time. A detailed phytochemical investigation on the aerial part of G. affine led to the isolation of two new esters of caffeoylquinic acid named (−) ethyl 1, 4-di- O-caffeoylquinate ( 1) and (−) methyl 1, 4-di- O-caffeoylquinate ( 2), together with 35 known compounds ( 337). Their structures were elucidated by spectroscopic data and first-order multiplet analysis. All the isolated compounds were tested for their xanthine oxidase inhibitory activity with an in vitro enzyme inhibitory screening assay. Among the tested compounds, 1 (IC 50 11.94 μmol·L –1) and 2 (IC 50 15.04 μmol·L –1) showed a good inhibitory activity. The current results supported the medical use of the plant.

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          Author and article information

          Journal
          CJNM
          Chinese Journal of Natural Medicines
          Elsevier
          1875-5364
          20 May 2018
          : 16
          : 5
          : 347-353
          Affiliations
          1Department of Traditional Chinese Medicine, Shanghai Institute of Pharmaceutical Industry, Shanghai 201203, China
          2Innovation Center of Traditional Chinese Medicine, China State Institute of Pharmaceutical Industry, Shanghai 201203, China
          3Sinopharm Health Industry Research Co., Ltd., Shanghai 201203, China
          Author notes
          *Corresponding author: FAN Si-Yang, E-mail: max_121@ 123456163.com

          These authors have no conflict of interest to declare.

          Article
          S1875-5364(18)30066-9
          10.1016/S1875-5364(18)30066-9
          Copyright © 2018 China Pharmaceutical University. Published by Elsevier B.V. All rights reserved.
          Funding
          Funded by: Natural Science Foundation of Shanghai
          Award ID: 15ZR1440100
          Funded by: National Natural Science Foundation of China
          Award ID: 81603279
          The work was supported by the Natural Science Foundation of Shanghai (No. 15ZR1440100) and the National Natural Science Foundation of China (No. 81603279).

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