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Alcoholic extract of ‘Bacopa monniera’ reduces the in vitro effects of morphine withdrawal in guinea-pig ileum
Thangarajan Sumathi ,
Mohamed Nayeem ,
Kedike Balakrishna ,
Gopalsamy Veluchamy ,
Sivasithamparam Niranjali Devaraj
October 2002
October 2002
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Abstract
The effect of the alcoholic extract of the whole plant of Bacopa monniera (Scrophulariaceae)
on morphine withdrawal was evaluated in vitro in guinea-pig ileum. After a 4 min in
vitro exposure to morphine, addition of naloxone induced a strong contraction. Addition
of various concentrations of the alcoholic extract of B. monniera (100-1000 microg/ml)
15 min before exposure to morphine reduced the naloxone-induced contraction in a dose-dependent
manner. The results suggest that B. monniera extract may be useful in reducing the
withdrawal symptoms induced by morphine.