The effect of the alcoholic extract of the whole plant of Bacopa monniera (Scrophulariaceae)
on morphine withdrawal was evaluated in vitro in guinea-pig ileum. After a 4 min in
vitro exposure to morphine, addition of naloxone induced a strong contraction. Addition
of various concentrations of the alcoholic extract of B. monniera (100-1000 microg/ml)
15 min before exposure to morphine reduced the naloxone-induced contraction in a dose-dependent
manner. The results suggest that B. monniera extract may be useful in reducing the
withdrawal symptoms induced by morphine.