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      Lysosomotropic agents

      , , , , ,
      Biochemical Pharmacology
      Elsevier BV

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          Immunochemotherapy of cancer with chlorambucil-carrying antibody.

          Cell-surface localizing heterologous antibodies against the mouse EL4 lymphoma and a human malignant melanoma could be bound to chlorambucil without causing the loss of the alkylating activity of chlorambucil or interfering with the reactivity of the antibodies with their respective tumour cells. When given to mice preinoculated with tumour cells 2, 24, 72, and 120 hours before the beginning of treatment the chlorambucil-bound antibody was a much more effective tumour inhibitor than chlorambucil or the antibody alone. In a patient with disseminated malignant melanoma injection of the chlorambucil-bound anti-melanoma antibody first locally into a few metastatic nodules and then by the intravenous route was followed by the regression of all the metastatic nodules.
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            Suggested Role of Lysosomal Lipid in the Contrasting Effects of ‘Triton WR-1339’ and Dextran on Tuberculous Infection

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              Author and article information

              Journal
              Biochemical Pharmacology
              Biochemical Pharmacology
              Elsevier BV
              00062952
              September 1974
              September 1974
              : 23
              : 18
              : 2495-2531
              Article
              10.1016/0006-2952(74)90174-9
              7f862a49-2001-4d73-afe6-a73cb9e846be
              © 1974

              http://www.elsevier.com/tdm/userlicense/1.0/

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