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      CovidGAN: Data Augmentation Using Auxiliary Classifier GAN for Improved Covid-19 Detection

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          Abstract

          Coronavirus (COVID-19) is a viral disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The spread of COVID-19 seems to have a detrimental effect on the global economy and health. A positive chest X-ray of infected patients is a crucial step in the battle against COVID-19. Early results suggest that abnormalities exist in chest X-rays of patients suggestive of COVID-19. This has led to the introduction of a variety of deep learning systems and studies have shown that the accuracy of COVID-19 patient detection through the use of chest X-rays is strongly optimistic. Deep learning networks like convolutional neural networks (CNNs) need a substantial amount of training data. Because the outbreak is recent, it is difficult to gather a significant number of radiographic images in such a short time. Therefore, in this research, we present a method to generate synthetic chest X-ray (CXR) images by developing an Auxiliary Classifier Generative Adversarial Network (ACGAN) based model called CovidGAN. In addition, we demonstrate that the synthetic images produced from CovidGAN can be utilized to enhance the performance of CNN for COVID-19 detection. Classification using CNN alone yielded 85% accuracy. By adding synthetic images produced by CovidGAN,the accuracy increased to 95%. We hope this method will speed up COVID-19 detection and lead to more robust systems of radiology.

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          Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China

          Summary Background A recent cluster of pneumonia cases in Wuhan, China, was caused by a novel betacoronavirus, the 2019 novel coronavirus (2019-nCoV). We report the epidemiological, clinical, laboratory, and radiological characteristics and treatment and clinical outcomes of these patients. Methods All patients with suspected 2019-nCoV were admitted to a designated hospital in Wuhan. We prospectively collected and analysed data on patients with laboratory-confirmed 2019-nCoV infection by real-time RT-PCR and next-generation sequencing. Data were obtained with standardised data collection forms shared by WHO and the International Severe Acute Respiratory and Emerging Infection Consortium from electronic medical records. Researchers also directly communicated with patients or their families to ascertain epidemiological and symptom data. Outcomes were also compared between patients who had been admitted to the intensive care unit (ICU) and those who had not. Findings By Jan 2, 2020, 41 admitted hospital patients had been identified as having laboratory-confirmed 2019-nCoV infection. Most of the infected patients were men (30 [73%] of 41); less than half had underlying diseases (13 [32%]), including diabetes (eight [20%]), hypertension (six [15%]), and cardiovascular disease (six [15%]). Median age was 49·0 years (IQR 41·0–58·0). 27 (66%) of 41 patients had been exposed to Huanan seafood market. One family cluster was found. Common symptoms at onset of illness were fever (40 [98%] of 41 patients), cough (31 [76%]), and myalgia or fatigue (18 [44%]); less common symptoms were sputum production (11 [28%] of 39), headache (three [8%] of 38), haemoptysis (two [5%] of 39), and diarrhoea (one [3%] of 38). Dyspnoea developed in 22 (55%) of 40 patients (median time from illness onset to dyspnoea 8·0 days [IQR 5·0–13·0]). 26 (63%) of 41 patients had lymphopenia. All 41 patients had pneumonia with abnormal findings on chest CT. Complications included acute respiratory distress syndrome (12 [29%]), RNAaemia (six [15%]), acute cardiac injury (five [12%]) and secondary infection (four [10%]). 13 (32%) patients were admitted to an ICU and six (15%) died. Compared with non-ICU patients, ICU patients had higher plasma levels of IL2, IL7, IL10, GSCF, IP10, MCP1, MIP1A, and TNFα. Interpretation The 2019-nCoV infection caused clusters of severe respiratory illness similar to severe acute respiratory syndrome coronavirus and was associated with ICU admission and high mortality. Major gaps in our knowledge of the origin, epidemiology, duration of human transmission, and clinical spectrum of disease need fulfilment by future studies. Funding Ministry of Science and Technology, Chinese Academy of Medical Sciences, National Natural Science Foundation of China, and Beijing Municipal Science and Technology Commission.
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            A survey on deep learning in medical image analysis

            Deep learning algorithms, in particular convolutional networks, have rapidly become a methodology of choice for analyzing medical images. This paper reviews the major deep learning concepts pertinent to medical image analysis and summarizes over 300 contributions to the field, most of which appeared in the last year. We survey the use of deep learning for image classification, object detection, segmentation, registration, and other tasks. Concise overviews are provided of studies per application area: neuro, retinal, pulmonary, digital pathology, breast, cardiac, abdominal, musculoskeletal. We end with a summary of the current state-of-the-art, a critical discussion of open challenges and directions for future research.
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              Principal component analysis

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                Author and article information

                Contributors
                Journal
                IEEE Access
                IEEE Access
                0063500
                ACCESS
                IAECCG
                Ieee Access
                IEEE
                2169-3536
                2020
                14 May 2020
                : 8
                : 91916-91923
                Affiliations
                [1 ]institutionMaharaja Agrasen Institute of Technology, institutionringgold 116449; New Delhi110086India
                [2 ]departmentArtificial Intelligence Department, divisionResearch Center for AI and IoT, institutionNear East University, institutionringgold 52988; 99138MersinTurkey
                [3 ]institutionState University of Ceará, institutionringgold 67843; Fortaleza60714903Brazil
                [4 ]institutionUniversity of Fortaleza, institutionringgold 28128; Fortaleza60811905Brazil
                Article
                10.1109/ACCESS.2020.2994762
                8043420
                34192100
                7f906217-31b3-4f11-9f96-e255e7534545
                This work is licensed under a Creative Commons Attribution 4.0 License. For more information, see https://creativecommons.org/licenses/by/4.0/

                This work is licensed under a Creative Commons Attribution 4.0 License. For more information, see https://creativecommons.org/licenses/by/4.0/

                History
                : 30 April 2020
                : 11 May 2020
                : 28 May 2020
                Page count
                Figures: 7, Tables: 1, Equations: 56, References: 32, Pages: 8
                Categories
                Computational and Artificial Intelligence
                Imaging
                Emerging Deep Learning Theories and Methods for Biomedical Engineering

                deep learning,convolutional neural networks,generative adversarial networks,synthetic data augmentation,covid-19 detection

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