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      Effect on Health-related Quality of Life of changes in mental health in children and adolescents

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          Abstract

          Background

          The objective of the study was to assess the effect of changes in mental health status on health-related quality of life (HRQOL) in children and adolescents aged 8 - 18 years.

          Methods

          A representative sample of Spanish children and adolescents aged 8-18 years completed the self-administered KIDSCREEN-52 questionnaire at baseline and after 3 years. Mental health status was measured using the Strengths and Difficulties Questionnaire (SDQ). Changes on SDQ scores over time were used to classify respondents in one of 3 categories (improved, stable, worsened). Data was also collected on gender, undesirable life events, and family socio-economic status. Changes in HRQOL were evaluated using effect sizes (ES). A multivariate analysis was performed to identify predictors of poor HRQOL at follow-up.

          Results

          Response rate at follow-up was 54% (n = 454). HRQOL deteriorated in all groups on most KIDSCREEN dimensions. Respondents who worsened on the SDQ showed the greatest deterioration, particularly on Psychological well-being (ES = -0.81). Factors most strongly associated with a decrease in HRQOL scores were undesirable life events and worsening SDQ score.

          Conclusions

          Changes in mental health status affect children and adolescents' HRQOL. Improvements in mental health status protect against poorer HRQOL while a worsening in mental health status is a risk factor for poorer HRQOL.

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          The Strengths and Difficulties Questionnaire (SDQ)--further evidence for its reliability and validity in a community sample of Dutch children and adolescents.

          Peter Muris, Cor Meesters, Frank van den Berg (2003)
          This study was a first attempt to examine the psychometric properties of the Strengths and Difficulties Questionnaire (SDQ) in Dutch youths. A large sample of normal children and adolescents ( N = 562) and their parents completed the SDQ along with a number of other psychopathology measures. Factor analysis of the SDQ yielded five factors that were in keeping with the hypothesised subscales of hyperactivity-inattention, emotional symptoms, peer problems, conduct problems, and prosocial behaviour. Furthermore, internal consistency, test-retest stability, and parent-youth agreement of the various SDQ scales were acceptable. Finally, the concurrent validity of the SDQ was good: that is, its scores correlated in a theoretically meaningful way with other measures of psychopathology. It can be concluded that the psychometric properties of the parent- and self-report version of the SDQ were satisfactory in this Dutch community sample. Moreover, the current data provide further support for the utility of the SDQ as an index of psychopathological symptoms in youths.
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            Assessment of health-related quality of life in children: a review of conceptual, methodological, and regulatory issues.

            Louis Matza, Andrine Swensen, Emuella Flood … (2015)
            Recently, the FDA has encouraged testing of medications among pediatric patients during drug development. Pharmaceutical companies have responded by conducting more clinical trials among children, and researchers are becoming aware of the unique challenges of assessing pediatric health outcomes, including health-related quality of life (HRQL). Like adults, children experience effects of illness and treatment beyond physiologic outcomes. Further pediatric HRQL research is necessary to examine these broader psychosocial outcomes and provide a thorough understanding of the effects of treatment on children's health status. The purpose of the current review is to discuss key regulatory and methodologic developments and provide guidance for future research on pediatric HRQL. This review of pediatric HRQL assessment includes five sections: 1). recent pediatric regulatory developments in the United States; 2). issues in defining and conceptualizing pediatric HRQL, including the importance of contextual variables such as family and peer systems; 3). methodologic issues (e.g., the proxy question, developmental differences, response sets) with recommendations for addressing these issues in clinical trials; 4). validated generic and condition-specific pediatric HRQL measures; and 5). a recommendation for additional research on the HRQL impact of childhood psychiatric disorders. It is advocated that assessment of HRQL among children should be conducted regularly as an integral part of drug development.
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              Health-related quality of life in children and adolescents in Germany: results of the BELLA study.

              Ulrike Ravens-Sieberer, Michael Erhart, Nora Wille … (2008)
              The self-perceived health or health-related quality of life of children and adolescents is increasingly recognised as a relevant outcome in medical practice and public health research. Identifying children and adolescents with particularly low health-related quality of life allows for an early detection of hidden morbidity and health care needs. The present study investigates health-related quality of life in children and adolescents in Germany. In the Mental Health Module (BELLA study) of the German National Health Interview and Examination Survey for Children and Adolescents (KiGGS), the parents of 2,863 children and adolescents aged 7-17 years, and 1,700 children and adolescents aged 11-17 years completed the KINDL-R quality of life questionnaire. The reliability (Cronbach's alpha=0.86) and validity of the measurements using the parent-reported KINDL-R were confirmed. Means and percentiles were calculated for the total sample as well as for strata defined by age, sex, geographical region (east/west), migration status and socioeconomic status. Expected differences in health-related quality of life of children and adolescents from different social backgrounds and with different health statuses were demonstrated by differences in the KINDL-R scores (effect size d up to 1.29). This study provides representative, normative data (self-report and parent-report) on the test scores of health-related quality of life (KINDL-R) for the population of children and adolescents in Germany in general, as well as in sociodemographic and socioeconomic subpopulations.
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                Author and article information

                Journal
                Journal ID (nlm-ta): Health Qual Life Outcomes
                Title: Health and Quality of Life Outcomes
                Publisher: BioMed Central
                ISSN (Electronic): 1477-7525
                Publication date Collection: 2009
                Publication date (Electronic): 23 December 2009
                Volume: 7
                Page: 103
                Affiliations
                [1 ]Catalan Agency for Health Technology Assessment and Research (CAHTA), Roc Boronat 81-95 2nd Floor, Barcelona 08005, Spain
                [2 ]Health Services Research Unit, Institut Municipal d'Investigació Mèdica (IMIM-hospital del mar), Dr Aiguader 88, Barcelona 08003, Spain
                [3 ]CIBER en Epidemiología y Salud Pública (CIBERESP), Dr Aiguader 88, Barcelona 08003, Spain
                [4 ]National Primary Care Research and Development Centre and NIHR School for Primary Care Research, University of Manchester, Williamson Building Oxford Road, Manchester M13 9PL, UK
                Article
                Publisher ID: 1477-7525-7-103
                DOI: 10.1186/1477-7525-7-103
                PMC ID: 2805624
                PubMed ID: 20030835
                SO-VID: 7fa0dee7-5e4d-446d-a24b-4bc076fbd89f
                Copyright © Copyright ©2009 Rajmil et al; licensee BioMed Central Ltd.
                License:

                This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

                History
                Date received : 28 June 2009
                Date accepted : 23 December 2009
                Categories
                Subject: Research

                ScienceOpen disciplines: Health & Social care
                Data availability:
                ScienceOpen disciplines: Health & Social care

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