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      Endocrine functions of bone in mineral metabolism regulation.

      The Journal of clinical investigation

      metabolism, Phosphates, Hyperphosphatemia, Humans, Homeostasis, physiology, Fibroblast Growth Factors, Energy Metabolism, Calcium, Calcitriol, Bone and Bones, Bone Density, Animals

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          Abstract

          Given the dramatic increase in skeletal size during growth, the need to preserve skeletal mass during adulthood, and the large capacity of bone to store calcium and phosphate, juxtaposed with the essential role of phosphate in energy metabolism and the adverse effects of hyperphosphatemia, it is not surprising that a complex systems biology has evolved that permits cross-talk between bone and other organs to adjust phosphate balance and bone mineralization in response to changing physiological requirements. This review examines the newly discovered signaling pathways involved in the endocrine functions of bone, such as those mediated by the phosphaturic and 1,25(OH)2D-regulating hormone FGF23, and the broader systemic effects associated with abnormalities of calcium and phosphate homeostasis.

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          Author and article information

          Journal
          10.1172/JCI36479
          2586800
          19033649

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