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      Multidrug resistant Mycobacterium leprae from patients with leprosy.

      Antimicrobial Agents and Chemotherapy
      Animals, Anti-Infective Agents, pharmacology, therapeutic use, Antibiotics, Antitubercular, Base Sequence, DNA Primers, DNA, Bacterial, drug effects, genetics, Drug Resistance, Microbial, Drug Resistance, Multiple, Genes, Bacterial, Humans, Leprostatic Agents, Leprosy, drug therapy, microbiology, Mice, Molecular Sequence Data, Mycobacterium leprae, Ofloxacin, Reverse Transcriptase Polymerase Chain Reaction, Rifampin

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          Abstract

          Sequences of the folP1, rpoB, and gyrA genes were analyzed for 88 isolates of Mycobacterium leprae from leprosy patients in Japan, Haiti, Indonesia, Pakistan, and the Philippines. Thirteen isolates (14.8%) showed representative mutations in more than two genes, suggesting the emergence of multidrug-resistant M. leprae.

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