Circulating microRNA signature in non-alcoholic fatty liver disease: from serum non-coding RNAs to liver histology and disease pathogenesis.

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Abstract

We used a screening strategy of global serum microRNA (miRNA) profiling, followed by a second stage of independent replication and exploration of liver expression of selected miRNAs to study: (1) the circulating miRNA signature associated with non-alcoholic fatty liver disease (NAFLD) progression and predictive power, (2) the role of miRNAs in disease biology and (3) the association between circulating miRNAs and features of the metabolic syndrome.

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Author and article information

Journal

Journal ID (iso-abbrev): Gut

Title: Gut

Publisher: BMJ

ISSN (Electronic): 1468-3288

ISSN (Print): 0017-5749

Publication date (Electronic): May 2015

Volume: 64

Issue: 5

Affiliations

[1 ] Department of Molecular Genetics and Biology of Complex Diseases, Institute of Medical Research A Lanari-IDIM, University of Buenos Aires-National Scientific and Technical Research Council (CONICET), Ciudad Autónoma de Buenos Aires, Argentina.

[2 ] Liver Unit, Medicine and Surgery Department, Hospital Abel Zubizarreta, Ciudad Autónoma de Buenos Aires, Argentina.

[3 ] Pathology Department, Hospital Diego Thompson, San Martin, Buenos Aires, Argentina.

[4 ] Department of Virology, School of Pharmacy and Biochemistry, University of Buenos Aires, Ciudad Autónoma de Buenos Aires, Argentina.

[5 ] Division of Gastroenterology, Hepatology and Nutrition, Department of Internal Medicine, Virginia Commonwealth University School of Medicine, Richmond, Virginia, USA.

[6 ] Liver Unit, Medicine and Surgery Department, Hospital Abel Zubizarreta, Ciudad Autónoma de Buenos Aires, Argentina Department of Clinical and Molecular Hepatology, Institute of Medical Research A Lanari-IDIM, University of Buenos Aires- National Scientific and Technical Research Council (CONICET), Ciudad Autónoma de Buenos Aires, Argentina.

Article

Publisher Item ID: gutjnl-2014-306996 Mid ID: NIHMS646958

DOI: 10.1136/gutjnl-2014-306996

PMC ID: 4277726

PubMed ID: 24973316

SO-VID: 7fc24d1e-db71-47d7-8528-bb5a4a2669ce

History

Keywords: Liver,Nonalcoholic Steatohepatitis

Data availability:

Keywords: Liver, Nonalcoholic Steatohepatitis

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