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      Digital Computer Simulation of the Nephron

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      Nephron

      S. Karger AG

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          Abstract

          A simulation model was used to explore the possible alterations of nephron function which could result in the development of the relationships between solute free water clearance and osmolar clearance observed in organomercurial induced diuresis. The data obtained and the relationships observed in these studies, in which mercurial diuresis was simulated by depression of sodium transport along the ascending limb of the loop of Henle, corresponds closely with experimental steady-state mercurial diuresis and is also consistent with the observed changes in renal function during early mercurial diuresis and when solute diuresis is superimposed upon steady-state mercurial diuresis. Interpretation of these results, with respect to the multivariate relationships within the structure of the simulated nephron, may lend support to the suggestions of a site of action of the organomercurials along the ascending limb of the loop of Henle.

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          Author and article information

          Journal
          NEF
          Nephron
          10.1159/issn.1660-8151
          Nephron
          S. Karger AG
          1660-8151
          2235-3186
          1969
          1969
          26 November 2008
          : 6
          : 5
          : 571-583
          Affiliations
          Departments of Pharmacology and Physiology, Northwestern University Medical School, Chicago, IL
          Article
          179756 Nephron 1969;6:571–583
          10.1159/000179756
          5384138
          © 1969 S. Karger AG, Basel

          Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

          Page count
          Pages: 13
          Categories
          Paper

          Cardiovascular Medicine, Nephrology

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