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      Autoregulation of Chronotropic Response of the Heart Through Pacemaker Stretch

      Cardiology

      S. Karger AG

      Mechanical stretch, Pacemaker activity, Autoregulation, Denervated heart, Transplanted heart, Amphibia, Reptilia, Aves, Mammals

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          Abstract

          Mechanical stretch is a fundamental biological stimulus for pacemaker activity. Stretch-sensitiveness enables the heart to autoregulate its rate in relation to venous return. Phylogenetically the importance of this primitive mechanism has been diminished by the emergence of neurohumoral influences which permit a quicker and more effective adaptation of cardiac performance. Nevertheless, the intrinsic autoregulatory mechanism is capable of independent operation and may support extrinsic neurohumoral influences under various conditions.

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          Author and article information

          Journal
          CRD
          Cardiology
          10.1159/issn.0008-6312
          Cardiology
          S. Karger AG
          0008-6312
          1421-9751
          1973
          1973
          29 October 2008
          : 58
          : 1
          : 45-64
          Affiliations
          Department of Physiology, Biophysics and Biochemistry, Medical College, Jodhpur
          Article
          169618 Cardiology 1973;58:45–64
          10.1159/000169618
          4145696
          © 1973 S. Karger AG, Basel

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          Page count
          Pages: 20
          Categories
          Editorial Review

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