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      The neocortical circuit: themes and variations.

      1 , 2
      Nature neuroscience

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          Abstract

          Similarities in neocortical circuit organization across areas and species suggest a common strategy to process diverse types of information, including sensation from diverse modalities, motor control and higher cognitive processes. Cortical neurons belong to a small number of main classes. The properties of these classes, including their local and long-range connectivity, developmental history, gene expression, intrinsic physiology and in vivo activity patterns, are remarkably similar across areas. Each class contains subclasses; for a rapidly growing number of these, conserved patterns of input and output connections are also becoming evident. The ensemble of circuit connections constitutes a basic circuit pattern that appears to be repeated across neocortical areas, with area- and species-specific modifications. Such 'serially homologous' organization may adapt individual neocortical regions to the type of information each must process.

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          Author and article information

          Journal
          Nat. Neurosci.
          Nature neuroscience
          1546-1726
          1097-6256
          Feb 2015
          : 18
          : 2
          Affiliations
          [1 ] UCL Institute of Neurology and UCL Department of Neuroscience, Physiology, and Pharmacology, University College London, London, UK.
          [2 ] Department of Physiology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA.
          Article
          nn.3917 NIHMS787031
          10.1038/nn.3917
          25622573
          7ff8c537-d824-4bc3-9833-7247ddc6bb85
          History

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