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      Evidence for the Existence of Atrial Natriuretic Factor-Containing Neurons in the Rat Brain

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          Abstract

          Immunoreactive atrial natriuretic factor- (ANF-)positive nerve fibers and cell bodies were observed in the preoptic area, hypothalamus, mesencephalon, and pons of rats. In colchicine-treated animals a large number of immunoreactive ANF-positive cell bodies were seen in the organum vasculosum of the lamina terminalis, in several hypothalamic nuclei (e.g. periventricular, arcuate, and ventral premammillary nuclei), and in the dorsolateral tegmental nuclei of the pons. Varicose nerve fibers containing ANF were generally observed in the vicinity of the cells. These findings indicate that a widespread network of ANF-containing neurons is present in the brain.

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          Author and article information

          Journal
          NEN
          Neuroendocrinology
          10.1159/issn.0028-3835
          Neuroendocrinology
          S. Karger AG
          0028-3835
          1423-0194
          1985
          1985
          28 March 2008
          : 40
          : 1
          : 92-94
          Affiliations
          aLaboratory of Clinical Science, NIMH; bHypertension and Endocrine Branch, NHLBI; cLaboratory of Clinical Studies, NIAAA, and dExperimental Therapeutics Branch, NINCDS, Bethesda, Md., USA
          Article
          124058 Neuroendocrinology 1985;40:92–94
          10.1159/000124058
          3881691
          © 1985 S. Karger AG, Basel

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          Page count
          Pages: 3
          Categories
          Original Paper

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