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      Molecular imaging of vascular endothelial growth factor receptors in graft arteriosclerosis.

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          Abstract

          Vascular endothelial growth factor (VEGF) signaling plays a key role in the pathogenesis of vascular remodeling, including graft arteriosclerosis. Graft arteriosclerosis is the major cause of late organ failure in cardiac transplantation. We used molecular near-infrared fluorescent imaging with an engineered Cy5.5-labeled single-chain VEGF tracer (scVEGF/Cy) to detect VEGF receptors and vascular remodeling in human coronary artery grafts by molecular imaging.

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          Author and article information

          Journal
          Arterioscler. Thromb. Vasc. Biol.
          Arteriosclerosis, thrombosis, and vascular biology
          1524-4636
          1079-5642
          Aug 2012
          : 32
          : 8
          Affiliations
          [1 ] Section of Cardiovascular Medicine, Yale University School of Medicine, New Haven, CT, USA.
          Article
          ATVBAHA.112.252510 NIHMS388578
          10.1161/ATVBAHA.112.252510
          3401339
          22723442

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