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      Novel drug-delivery systems for patients with chronic rhinosinusitis

      Drug Design, Development and Therapy

      Dove Medical Press

      paranasal sinuses, topical therapy, nebulized antibiotics, clinical trials

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          Abstract

          Chronic rhinosinusitis, one of the most common chronic medical complaints in the United States, seems to be increasing in incidence and prevalence, and has a significant impact on quality of life. Topical forms of medical therapy represent an attractive alternative for drug delivery to the nasal cavity and paranasal sinuses. Topical drug delivery has the advantage of directly acting on the site of inflammation, producing a higher concentration at the target site while avoiding systemic side effects. Although considerable research has been undertaken into improving nasal formulations in order to enhance absorption, little attention has so far been directed to upgrading the delivery devices. The aim of this review is to present current knowledge on the novel drug-delivery devices in use in the management of chronic rhinosinusitis patients, and to present the current available knowledge on topical drug penetration into the sinuses using various delivery devices. Additionally, methods used to enhance fluid sinus deposition are presented and the published clinical studies on the results of nebulized antibiotics in the treatment of chronic rhinosinusitis patients are discussed.

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          Author and article information

          Journal
          Drug Des Devel Ther
          Drug Des Devel Ther
          Drug Design, Development and Therapy
          Dove Medical Press
          1177-8881
          2012
          31 May 2012
          : 6
          : 125-132
          Affiliations
          Department of Otolaryngology, University of Medicine and Pharmacy Cluj-Napoca, Cluj-Napoca, Romania
          Author notes
          Correspondence: Silviu Albu, Department of Otolaryngology, University of Medicine and Pharmacy, Cluj-Napoca, Str Republicii nr 18, 400015 Cluj-Napoca, Romania, Fax +40 264 598278, Email silviualbu63@ 123456gmail.com
          Article
          dddt-6-125
          10.2147/DDDT.S25199
          3383347
          22745531
          © 2012 Albu, publisher and licensee Dove Medical Press Ltd

          This is an Open Access article which permits unrestricted noncommercial use, provided the original work is properly cited.

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