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      Role of KAI1/CD82 polymorphisms in colon cancer risk in Han Chinese population.

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          Abstract

          The aim of this study is to investigate the associations between KAI1/CD82 gene polymorphisms and colorectal cancer (CRC)-risk predisposition. We undertook a case-control study to analyze two KAI1/CD82 polymorphisms (exon 3 -29166 C>T and exon 9 -52840 C>A) in an Han Chinese population, by extraction of genomic DNA from the peripheral blood of 356 patients with CRC and 378 control participants, and performed KAI1/CD82 genotyping using DNA sequencing. The obtained results indicated that overall, no statistically significant association was observed in exon 9 (-52840 C>A). Nevertheless, exon 3 (-29166 C>T) genotype was at increased risk of CRC (P = 0.006; odds ratio = 1.299, CI 95% 1.058-1.549). Furthermore, -29166 T allele CRCs were more significantly common in patients with tumor size of >4 cm than C allele CRC and in cases of poor differentiation and advanced pathological stage. These findings led us to conclude that polymorphism in exon 3 (-29166 C>T) was observed to be associated with susceptibility of CRC. However, exon 9 (-52840 C>A) polymorphism showed no correlation to CRC susceptibility. Nevertheless, further investigation with a larger sample size is needed to support our results.

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          Author and article information

          Journal
          Med. Oncol.
          Medical oncology (Northwood, London, England)
          1559-131X
          1357-0560
          2013
          : 30
          : 3
          Affiliations
          [1 ] Department of Gastroenterology, Affiliated Hospital of Binzhou Medical College, No. 661, Yellow-River Second Street, 256600 Binzhou, China. mazhenbin@yeah.net
          Article
          10.1007/s12032-013-0668-7
          23873015
          8072921d-ada7-4ce9-b246-4ff211840e0a
          History

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