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      Importance of Early Postnatal Germ Cell Maturation for Fertility of Cryptorchid Males


      Hormone Research in Paediatrics

      S. Karger AG

      Cryptorchidism, Fertility, Adult dark spermatogonia

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          Patients/Method: Twenty-seven adults who underwent an orchidopexy before 2 years of age have recently had their spermiograms analyzed. Results: Sixty-three percent of them had a normal sperm count; their germ cells had undergone the second stage of maturation and adult dark (Ad) spermatogonia were present at the time of surgery 20–25 years earlier. In contrast, 37% of them were infertile despite a seemingly successful orchidopexy; they had impaired second-step germ cell maturation and Ad spermatogonia were absent at orchidopexy. Conclusions: Transformation of gonocytes into Ad spermatogonia is crucial for fertility. This underscores the importance of a testicular biopsy at orchidopexy in order to identify those who could benefit from early LH-RH treatment after orchidopexy.

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          Author and article information

          Horm Res Paediatr
          Hormone Research in Paediatrics
          S. Karger AG
          22 June 2001
          : 55
          : 1
          : 6-10
          Kindertagesklinik, Liestal, Switzerland
          49956 Horm Res 2001;55:6–10
          © 2001 S. Karger AG, Basel

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          Page count
          Figures: 4, Tables: 1, References: 49, Pages: 5
          Original Paper


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