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Minichromosomal variable surface glycoprotein genes and molecular karyotypes of Trypanosoma (Nannomonas) congolense
January 1986
January 1986
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Abstract
Employing orthogonal-field-alternation gel electrophoresis (OFAGE), we have separated
chromosome-sized DNA molecules from Trypanosoma (Nannomonas) congolense clones, the
clones being derived from several distinct antigenic repertoires. Trypanosome clones
that belong to a specific antigenic repertoire appear to have a chromosome pattern
characteristic of that particular repertoire. Hybridization of the separated chromosomes
with cloned DNA fragments encoding variable surface glycoproteins revealed the presence
of two different T.(N.) congolense variable surface glycoprotein genes on mini-chromosomes
(mc) and the modes by which these genes may be activated: one by duplicative and the
other by non-duplicative activation.