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      Association between plasma xanthine oxidoreductase activity and in-hospital outcomes in patients with stable coronary artery disease after percutaneous coronary intervention

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          Abstract

          Objectives

          Reactive oxygen species generated by xanthine oxidoreductase (XOR) are associated with the progression of atherosclerosis. However, changes in plasma XOR (pXOR) activity after percutaneous coronary intervention (PCI) for stable coronary artery disease (CAD) remains unknown.

          Methods

          Herein, we compared the change in the pXOR activity in patients undergoing PCI with that in patients undergoing coronary angiography (CAG) and further evaluated the relation between changes in pXOR activity and in-hospital and long-term outcomes of patients undergoing PCI. The pXOR activity of 80 consecutive patients who underwent PCI and 25 patients who underwent CAG during the hospitalization was analyzed daily. The percentage changes from baseline regulated time interval was evaluated.

          Results

          We found that although pXOR activity decreased after PCI, and remained low until discharge, no significant changes were observed in patients undergoing CAG. Furthermore, among the patients undergoing PCI, those who experienced in-hospital adverse events, had a higher percentage of pXOR reduction 3 days after PCI. There was no association between these changes and long-term events.

          Conclusions

          A significant change in pXOR activity was observed in patients undergoing PCI than in patients undergoing CAG, and there seems to be a correlation between the in-hospital outcomes and the percentage reduction from baseline in pXOR activity.

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          Most cited references33

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          G*Power 3: A flexible statistical power analysis program for the social, behavioral, and biomedical sciences

          G*Power (Erdfelder, Faul, & Buchner, 1996) was designed as a general stand-alone power analysis program for statistical tests commonly used in social and behavioral research. G*Power 3 is a major extension of, and improvement over, the previous versions. It runs on widely used computer platforms (i.e., Windows XP, Windows Vista, and Mac OS X 10.4) and covers many different statistical tests of the t, F, and chi2 test families. In addition, it includes power analyses for z tests and some exact tests. G*Power 3 provides improved effect size calculators and graphic options, supports both distribution-based and design-based input modes, and offers all types of power analyses in which users might be interested. Like its predecessors, G*Power 3 is free.
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            2019 ESC Guidelines for the diagnosis and management of chronic coronary syndromes

              Bookmark
              • Record: found
              • Abstract: not found
              • Article: not found

              Standardized bleeding definitions for cardiovascular clinical trials: a consensus report from the Bleeding Academic Research Consortium.

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                Author and article information

                Contributors
                Role: Data curationRole: Formal analysisRole: InvestigationRole: MethodologyRole: Writing – original draft
                Role: Data curation
                Role: Data curation
                Role: Data curation
                Role: MethodologyRole: ResourcesRole: Writing – review & editing
                Role: MethodologyRole: ResourcesRole: Writing – review & editing
                Role: MethodologyRole: ResourcesRole: Writing – review & editing
                Role: Writing – review & editing
                Role: Writing – review & editing
                Role: Writing – review & editing
                Role: ConceptualizationRole: Data curationRole: InvestigationRole: SupervisionRole: ValidationRole: Writing – original draftRole: Writing – review & editing
                Role: Editor
                Journal
                PLoS One
                PLoS One
                plos
                PLoS ONE
                Public Library of Science (San Francisco, CA USA )
                1932-6203
                14 September 2021
                2021
                : 16
                : 9
                : e0257227
                Affiliations
                [1 ] Division of Cardiology, Internal Medicine III, Hamamatsu University School of Medicine, Hamamatsu, Japan
                [2 ] Sanwa Kagaku Kenkyusho Co., Ltd., Aichi, Japan
                The Second Affilated Hospital, Zhejiang University School of Medicine, CHINA
                Author notes

                Competing Interests: TM, TN, and SA belong to the Sanwa Kagaku Kenkyusho Co., Ltd., which is a company marketing uric acid lowering drugs. The funder provided support in the form of salaries for TM, TN, and SA, but had no role in the study design, data collection and analysis, decision to publish, or preparation of the manuscript. This does not alter our adherence to PLOS ONE policies on sharing data and materials. The specific roles of these authors are articulated in the “authors’ contributions section”.

                Author information
                https://orcid.org/0000-0001-6641-1062
                https://orcid.org/0000-0001-9630-951X
                https://orcid.org/0000-0002-6792-8458
                Article
                PONE-D-21-00895
                10.1371/journal.pone.0257227
                8439489
                80aa3cf1-7ffe-4322-a6a7-3044007a4d41
                © 2021 Sato et al

                This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

                History
                : 10 January 2021
                : 26 August 2021
                Page count
                Figures: 3, Tables: 2, Pages: 12
                Funding
                This study was conducted as a collaborative research between Hamamatsu University School of Medicine and Sanwa Kagaku Kenkyusho Co., Ltd. Sanwa Kagaku Kenkyusho Co., Ltd. did not fund this study, but provided support in the form of salaries for TM, TN, and SA. The specific roles of these authors are articulated in the “authors’ contributions section”. The funder had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.
                Categories
                Research Article
                Medicine and Health Sciences
                Medical Conditions
                Cardiovascular Diseases
                Coronary Heart Disease
                Medicine and Health Sciences
                Cardiology
                Cardiovascular Medicine
                Cardiovascular Diseases
                Coronary Heart Disease
                Medicine and Health Sciences
                Vascular Medicine
                Coronary Heart Disease
                Research and Analysis Methods
                Research Design
                Clinical Research Design
                Adverse Events
                Medicine and Health Sciences
                Surgical and Invasive Medical Procedures
                Cardiovascular Procedures
                Angioplasty
                Coronary Angioplasty
                Biology and Life Sciences
                Anatomy
                Body Fluids
                Blood
                Blood Plasma
                Medicine and Health Sciences
                Anatomy
                Body Fluids
                Blood
                Blood Plasma
                Biology and Life Sciences
                Physiology
                Body Fluids
                Blood
                Blood Plasma
                Medicine and Health Sciences
                Cardiology
                Myocardial Infarction
                Physical Sciences
                Chemistry
                Chemical Compounds
                Acids
                Uric Acid
                Medicine and Health Sciences
                Medical Conditions
                Cardiovascular Diseases
                Coronary Heart Disease
                Stable Coronary Artery Disease
                Medicine and Health Sciences
                Cardiology
                Cardiovascular Medicine
                Cardiovascular Diseases
                Coronary Heart Disease
                Stable Coronary Artery Disease
                Medicine and Health Sciences
                Vascular Medicine
                Coronary Heart Disease
                Stable Coronary Artery Disease
                Medicine and Health Sciences
                Vascular Medicine
                Ischemia
                Custom metadata
                All relevant data are within the paper and its Supporting Information files.

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