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Pubertal ovarian hormone exposure reduces the number of myelinated axons in the splenium of the rat corpus callosum
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Abstract
The size of the female rat corpus callosum decreases in response to pubertal ovarian
hormone exposure, but the underlying changes in axonal composition have not been examined.
In the current study, animals underwent ovariectomy or sham surgery at day 20, and
the number of myelinated and unmyelinated axons were examined in young adulthood (2
months) using electron microscopy. Ovariectomized animals had a greater number of
myelinated axons compared to intact animals, while total axon number was not affected.
Ovarian hormone exposure seems to limit the number of axons that become myelinated
in the splenium, while not affecting the number of axons crossing through the region.