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      Aldosterone's mechanism of action: roles of lysine-specific demethylase 1, caveolin and striatin.

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          Abstract

          Aldosterone's functions and mechanisms of action are different depending on the tissue and the environmental condition. The mineralocorticoid receptor is present in tissues beyond epithelial cells, including the heart and vessels. Furthermore, aldosterone has direct adverse effects by both genomic and rapid/nongenomic actions not only through a nuclear receptor but also through caveolae-mediated intracellular events. Also, multiple environmental-genetic interactions play an important role in salt-sensitive hypertension (SSH) and aldosterone modulation. These findings have reshaped our vision of aldosterone's role in cardiovascular pathophysiology. This review describes new mediators of aldosterone's mechanisms of action: lysine-specific demethylase 1 (LSD1), caveolin 1 (cav-1) and striatin.

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          Author and article information

          Journal
          Curr. Opin. Nephrol. Hypertens.
          Current opinion in nephrology and hypertension
          Ovid Technologies (Wolters Kluwer Health)
          1473-6543
          1062-4821
          Jan 2014
          : 23
          : 1
          Affiliations
          [1 ] aDivision of Endocrinology, Diabetes and Hypertension, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School. Boston, Massachusetts, USA bDepartment of Endocrinology, School of Medicine, Pontificia Universidad Catolica De Chile, Santiago, Chile.
          Article
          10.1097/01.mnh.0000436543.48391.e0
          24275769

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