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      Administration of Recombinant Human Insulin-Like Growth Factor I to Pigs: Determination of Circulating Half-Lives and Chomatographic Profiles

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          Recombinant human insulin-like growth factor I (IGF-I) was injected daily (4 or 8 mg/pig) as an intra-arterial bolus into pigs for 3 consecutive days and the serum IGF-I concentration was measured to determine disappearance profiles. IGF-I partitioned to a fast component (half-life, t<sub>½</sub> = 5.7 min) and a slow component (t<sub>½</sub> = 253 min) in pig serum. Chromatography of serum revealed that the fast component comprised unbound IGF-I, whereas the slow component comprised IGF-I bound to 40- and 150-kD serum IGF-binding proteins. In addition, administration of exogenous IGF-I caused significant hypoglycemia.

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          Author and article information

          Horm Res Paediatr
          Hormone Research in Paediatrics
          S. Karger AG
          02 December 2008
          : 31
          : 3
          : 138-142
          aDepartment of Dairy and Animal Science, Pennsylvania State University, University Park, Pa., and bPitman-Moore, Inc., Northbrook, Ill., USA
          181103 Horm Res 1989;31:138–142
          © 1989 S. Karger AG, Basel

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          Pages: 5
          Original Paper


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