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Analgesic Effects of Transcutaneous Ultrasound Nerve Stimulation in a Rat Model of Oxaliplatin-Induced Mechanical Hyperalgesia and Cold Allodynia.

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      Abstract

      This study investigated the effects and underlying mechanisms of therapeutic ultrasound (TUS) in a rat model of oxaliplatin-induced peripheral neuropathy. Animals received a total of eight injections with oxaliplatin (4 mg/kg), administered at 3-d intervals. TUS intervention (1 MHz, 0.5 W/cm(2)) started on the fifth oxaliplatin administration and continued for 10 consecutive d. Sensory behavioral examinations, protein levels of transient receptor potential channels (TRPM8 and TRPV1) in dorsal root ganglia (DRG) and substance P (SP) in spinal dorsal horn were examined. Results indicated that TUS can reduce mechanical and cold hyper-responsive behaviors caused by repeated administration of oxaliplatin. Oxaliplatin-related increases in protein levels of TRPM8 in DRG and SP in the dorsal horn were also reduced after TUS. Taken together, the results revealed beneficial effects of TUS on oxaliplatin-induced mechanical hyperalgesia and cold allodynia and suggested involvement of TUS biochemicals in suppressing TRPM8 in DRG and SP in spinal cords.

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      Affiliations
      [1 ] Department of Physical Therapy, Graduate Institute of Rehabilitation Science, China Medical University, Taichung, Taiwan. Electronic address: sherrie@mail.cmu.edu.tw.
      [2 ] Department of Physical Therapy, Hung-Kuang University, Taichung, Taiwan.
      [3 ] Department of Physical Therapy, Graduate Institute of Rehabilitation Science, China Medical University, Taichung, Taiwan.
      [4 ] Kao-An Physical Medicine and Rehabilitation Clinic, Taichung, Taiwan.
      Journal
      Ultrasound Med Biol
      Ultrasound in medicine & biology
      Elsevier BV
      1879-291X
      0301-5629
      Jul 2017
      : 43
      : 7
      28433438
      S0301-5629(17)30102-3
      10.1016/j.ultrasmedbio.2017.03.002

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