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      Study on Chronic Renal Injuries Induced by Carbon Tetrachloride: Selective Inhibition of the Nephrotoxicity by Irradiation

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          Abstract

          Carbon tetrachloride (CC1<sub>4</sub>) was intraperitoneally injected into Balb/c mice 4 times at biweekly intervals, and the morphological changes of the liver and kidney were examined during 12 weeks after the last injection. The renal injuries progressed in spite of cessation of CC1<sub>4</sub> treatment; microcysts with tubular-cell degeneration were manifest on day 42 after the last injection of CC1<sub>4</sub>. At the end of the experiment, however, interstitial fíbrosis with inflammatory cell infiltration was much more prominent. Glomerular changes with IgG deposits also developed following the tubulointerstitial changes. The CC1<sub>4</sub> treatment induced liver damage as well, but it promptly subsided without formation of cirrhosis. The CC1<sub>4</sub> nephrotoxicity was completely inhibited by whole body irradiation (200 rad) exposed at each injection of CC1<sub>4</sub>. In contrast, the hepatic damage was not changed by irradiation. These results seem to indicate etiologic independence of renal and hepatic events induced by CC1<sub>4</sub> treatment. It is also suggested that chronic CC1<sub>4</sub> nephrotoxicity is mediated, at least in part, by radiosensitive responses of the mice themselves.

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          Author and article information

          Journal
          NEF
          Nephron
          10.1159/issn.1660-8151
          Nephron
          S. Karger AG
          1660-8151
          2235-3186
          1992
          1992
          11 December 2008
          : 60
          : 1
          : 68-73
          Affiliations
          aFirst Department of Internal Medicine and bDepartment of Postgraduate Medical Education Center, Chiba University School of Medicine; cChiba Social Security Hospital, Chiba City, Chiba, Japan
          Article
          186707 Nephron 1992;60:68–73
          10.1159/000186707
          1738417
          © 1992 S. Karger AG, Basel

          Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

          Page count
          Pages: 6
          Categories
          Original Paper

          Cardiovascular Medicine, Nephrology

          Whole body irradiation, Nephrotoxicity, Carbon tetachloride

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