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      Assessment of ?Ca2+-antagonist? effects of drugs in K+-depolarized smooth muscle : Differentiation of antagonist subgroups

      Naunyn-Schmiedeberg's Archives of Pharmacology
      Springer Nature

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          Most cited references22

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          Some quantitative uses of drug antagonists.

          Various applications of pA(x) measurements are discussed based on the hypothesis that drugs and drug antagonists compete for receptors according to the mass law. Examples are given illustrating the use of pA(x) measurements to identify agonists which act on the same receptors and to compare the receptors of different tissues. Tests of competitive and noncompetitive antagonism are considered in relation to the antagonisms acetylcholine-atropine, histamine-atropine and acetylcholine-cinchonidine. A new measure, pA(h), is introduced to express the activity of unsurmountable antagonists.
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            A modification of receptor theory.

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              Specific pharmacology of calcium in myocardium, cardiac pacemakers, and vascular smooth muscle.

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                Author and article information

                Journal
                Naunyn-Schmiedeberg's Archives of Pharmacology
                Naunyn-Schmiedeberg's Arch. Pharmacol.
                Springer Nature
                0028-1298
                1432-1912
                1982
                1982
                : 318
                : 3
                : 234-240
                Article
                10.1007/BF00500485
                80e502f8-d167-4b18-bd1f-01c248772745
                © 1982
                History

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