G. Rindi , 1 , G. Klöppel 2 , H. Alhman 3 , M. Caplin 4 , A. Couvelard 5 , W. W. de Herder 6 , B. Erikssson 7 , A. Falchetti 8 , M. Falconi 9 , P. Komminoth 10 , M. Körner 11 , J. M. Lopes 12 , A-M. McNicol 13 , O. Nilsson 14 , A. Perren 15 , A. Scarpa 16 , J-Y. Scoazec 17 , B. Wiedenmann 18 , and all other Frascati Consensus Conference participants
12 September 2006
The need for standards in the management of patients with endocrine tumors of the digestive system prompted the European Neuroendocrine Tumor Society (ENETS) to organize a first Consensus Conference, which was held in Frascati (Rome) and was based on the recently published ENETS guidelines on the diagnosis and treatment of digestive neuroendocrine tumors (NET). Here, we report the tumor–node–metastasis proposal for foregut NETs of the stomach, duodenum, and pancreas that was designed, discussed, and consensually approved at this conference. In addition, we report the proposal for a working formulation for the grading of digestive NETs based on mitotic count and Ki-67 index. This proposal, which needs to be validated, is meant to help clinicians in the stratification, treatment, and follow-up of patients.