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      Plants of Genus Mentha: From Farm to Food Factory

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          Abstract

          Genus Mentha, a member of Lamiaceae family, encompasses a series of species used on an industrial scale and with a well-described and developed culture process. Extracts of this genus are traditionally used as foods and are highly valued due to the presence of significant amounts of antioxidant phenolic compounds. Many essential oil chemotypes show distinct aromatic flavor conferred by different terpene proportions. Mint extracts and their derived essential oils exert notable effects against a broad spectrum of bacteria, fungi or yeasts, tested both in vitro or in various food matrices. Their chemical compositions are well-known, which suggest and even prompt their safe use. In this review, genus Mentha plant cultivation, phytochemical analysis and even antimicrobial activity are carefully described. Also, in consideration of its natural origin, antioxidant and antimicrobial properties, a special emphasis was given to mint-derived products as an interesting alternative to artificial preservatives towards establishing a wide range of applications for shelf-life extension of food ingredients and even foodstuffs. Mentha cultivation techniques markedly influence its phytochemical composition. Both extracts and essential oils display a broad spectrum of activity, closely related to its phytochemical composition. Therefore, industrial implementation of genus Mentha depends on its efficacy, safety and neutral taste.

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          Discovery and resupply of pharmacologically active plant-derived natural products: A review

          Medicinal plants have historically proven their value as a source of molecules with therapeutic potential, and nowadays still represent an important pool for the identification of novel drug leads. In the past decades, pharmaceutical industry focused mainly on libraries of synthetic compounds as drug discovery source. They are comparably easy to produce and resupply, and demonstrate good compatibility with established high throughput screening (HTS) platforms. However, at the same time there has been a declining trend in the number of new drugs reaching the market, raising renewed scientific interest in drug discovery from natural sources, despite of its known challenges. In this survey, a brief outline of historical development is provided together with a comprehensive overview of used approaches and recent developments relevant to plant-derived natural product drug discovery. Associated challenges and major strengths of natural product-based drug discovery are critically discussed. A snapshot of the advanced plant-derived natural products that are currently in actively recruiting clinical trials is also presented. Importantly, the transition of a natural compound from a “screening hit” through a “drug lead” to a “marketed drug” is associated with increasingly challenging demands for compound amount, which often cannot be met by re-isolation from the respective plant sources. In this regard, existing alternatives for resupply are also discussed, including different biotechnology approaches and total organic synthesis. While the intrinsic complexity of natural product-based drug discovery necessitates highly integrated interdisciplinary approaches, the reviewed scientific developments, recent technological advances, and research trends clearly indicate that natural products will be among the most important sources of new drugs also in the future.
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            Essential Oils in Food Preservation: Mode of Action, Synergies, and Interactions with Food Matrix Components

            Essential oils are aromatic and volatile liquids extracted from plants. The chemicals in essential oils are secondary metabolites, which play an important role in plant defense as they often possess antimicrobial properties. The interest in essential oils and their application in food preservation has been amplified in recent years by an increasingly negative consumer perception of synthetic preservatives. Furthermore, food-borne diseases are a growing public health problem worldwide, calling for more effective preservation strategies. The antibacterial properties of essential oils and their constituents have been documented extensively. Pioneering work has also elucidated the mode of action of a few essential oil constituents, but detailed knowledge about most of the compounds’ mode of action is still lacking. This knowledge is particularly important to predict their effect on different microorganisms, how they interact with food matrix components, and how they work in combination with other antimicrobial compounds. The main obstacle for using essential oil constituents as food preservatives is that they are most often not potent enough as single components, and they cause negative organoleptic effects when added in sufficient amounts to provide an antimicrobial effect. Exploiting synergies between several compounds has been suggested as a solution to this problem. However, little is known about which interactions lead to synergistic, additive, or antagonistic effects. Such knowledge could contribute to design of new and more potent antimicrobial blends, and to understand the interplay between the constituents of crude essential oils. The purpose of this review is to provide an overview of current knowledge about the antibacterial properties and antibacterial mode of action of essential oils and their constituents, and to identify research avenues that can facilitate implementation of essential oils as natural preservatives in foods.
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              Antibacterial Effects of the Essential Oils of Commonly Consumed Medicinal Herbs Using an In Vitro Model

              The chemical composition and antibacterial activity of essential oils from 10 commonly consumed herbs: Citrus aurantium, C. limon, Lavandula angustifolia, Matricaria chamomilla, Mentha piperita, M. spicata, Ocimum basilicum, Origanum vulgare, Thymus vulgaris and Salvia officinalis have been determined. The antibacterial activity of these oils and their main components; i.e. camphor, carvacrol, 1,8-cineole, linalool, linalyl acetate, limonene, menthol, α-pinene, β-pinene, and thymol were assayed against the human pathogenic bacteria Bacillus subtilis, Enterobacter cloacae, Escherichia coli O157:H7, Micrococcus flavus, Proteus mirabilis, Pseudomonas aeruginosa, Salmonella enteritidis, S. epidermidis, S. typhimurium, and Staphylococcus aureus. The highest and broadest activity was shown by O. vulgare oil. Carvacrol had the highest antibacterial activity among the tested components.
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                Author and article information

                Journal
                Plants (Basel)
                Plants (Basel)
                plants
                Plants
                MDPI
                2223-7747
                04 September 2018
                September 2018
                : 7
                : 3
                : 70
                Affiliations
                [1 ]Medical Ethics and Law Research Center, Shahid Beheshti University of Medical Sciences, Tehran 1983963113, Iran; bahar.salehi007@ 123456gmail.com
                [2 ]Student Research Committee, Shahid Beheshti University of Medical Sciences, Tehran 1983963113, Iran
                [3 ]Department of Biology and Ecology, Faculty of Sciences and Mathematics, University of Niš, Višegradska 33, 18000 Niš, Serbia; zstojanovicradic@ 123456yahoo.com
                [4 ]Department of Pharmacy, Faculty of Medicine, University of Niš, Boulevard Dr Zorana Đinđića 81, 18000 Niš, Serbia; jekamatejic@ 123456gmail.com
                [5 ]Department of Pharmaceutical Technology, Avicenna Tajik State Medical University, Rudaki 139, Dushanbe 734003, Tajikistan; shfarukh@ 123456mail.ru
                [6 ]Institute of Fermentation Technology and Microbiology, Lodz University of Technology, 90-924 Łódź, Poland; hubert.antolak@ 123456gmail.com (H.A.); dorota.kregiel@ 123456p.lodz.pl (D.K.)
                [7 ]Molecular and Applied Mycology and Plant Pathology Laboratory, Department of Botany, Centre of Advanced Study, University of Calcutta, 35, Ballygunge Circular Road, Kolkata 700019, India; surjitsen09@ 123456gmail.com (S.S.); krish_paper@ 123456yahoo.com (K.A.)
                [8 ]Department of Medical Parasitology, Zabol University of Medical Sciences, Zabol 61663335, Iran
                [9 ]Zabol Medicinal Plants Research Center, Zabol University of Medical Sciences, Zabol 61615585, Iran; razieh.sharifirad@ 123456gmail.com
                [10 ]Department of Nutrition and Dietetics, Faculty of Pharmacy, University of Concepcion, Concepcion, 4070386 VIII-Bio Bio Region, Chile
                [11 ]Research Group on Community Nutrition and Oxidative Stress and CIBEROBN (Physiopathology of Obesity and Nutrition), University of Balearic Islands, 07122 Palma de Mallorca, Spain; tosugo@ 123456hotmail.com
                [12 ]Faculty of Medicine, University of Porto, Alameda Prof. Hernâni Monteiro, 4200-319 Porto, Portugal
                [13 ]Institute for Research and Innovation in Health (i3S), University of Porto, 4200-135 Porto, Portugal
                [14 ]Phytochemistry Research Center, Shahid Beheshti University of Medical Sciences, Tehran 11369, Iran
                [15 ]Department of Chemistry, Richardson College for the Environmental Science Complex, The University of Winnipeg, Winnipeg, MB R3B 2E9, Canada
                Author notes
                [* ]Correspondence: mehdi_sharifirad@ 123456yahoo.com (M.S.-R.); martorellpons@ 123456gmail.com (M.M.); ncmartins@ 123456med.up.pt (N.M.); javad.sharifirad@ 123456gmail.com (J. S.-R.); Tel.: +98-543-22-51-790 (M.S.-R); +56-41-266-1671 (M.M.); +35-12-2551-2100 (N.M.); +98-21-8820-0104 (J.S.-R.)
                Author information
                https://orcid.org/0000-0002-6900-9797
                https://orcid.org/0000-0003-0378-8887
                https://orcid.org/0000-0002-4006-6464
                https://orcid.org/0000-0003-3183-7623
                https://orcid.org/0000-0001-8656-6838
                https://orcid.org/0000-0002-5934-5201
                https://orcid.org/0000-0002-7301-8151
                Article
                plants-07-00070
                10.3390/plants7030070
                6161068
                30181483
                80f2c560-1d7e-4cf3-b235-ba91051067a2
                © 2018 by the authors.

                Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license ( http://creativecommons.org/licenses/by/4.0/).

                History
                : 30 July 2018
                : 29 August 2018
                Categories
                Review

                mentha genus,essential oil,chemotypes,plant extracts,culture conditions,food preservatives,antimicrobials

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