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      The inflammasome NLRs in immunity, inflammation, and associated diseases.

      1 , ,
      Annual review of immunology
      Annual Reviews

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          Abstract

          Inflammasome activation leads to caspase-1 activation, which causes the maturation and secretion of pro-IL-1β and pro-IL-18 among other substrates. A subgroup of the NLR (nucleotide-binding domain, leucine-rich repeat containing) proteins are key mediators of the inflammasome. Studies of gene-deficient mice and cells have implicated NLR inflammasomes in a host of responses to a wide range of microbial pathogens, inflammatory diseases, cancer, and metabolic and autoimmune disorders. Determining exactly how the inflammasome is activated in these diseases and disease models remains a challenge. This review presents and integrates recent progress in the field.

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          Author and article information

          Journal
          Annu Rev Immunol
          Annual review of immunology
          Annual Reviews
          1545-3278
          0732-0582
          2011
          : 29
          Affiliations
          [1 ] Department of Microbiology and Immunology, Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, 27599, USA. antigen@med.unc.edu
          Article
          NIHMS596973
          10.1146/annurev-immunol-031210-101405
          4067317
          21219188
          80f2dbcd-4fb8-42c3-a68b-50bd4fc8584b
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