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      Sudden death in a young female with an under-recognised coronary anomaly

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          Abstract

          Anomalies of coronary number and course represent an opinion-dividing topic in cardiopathology, particularly for their relationship with sudden cardiac death.

          To the best of our knowledge, we herein report the first fatal case of a young female whose coronary anatomy was characterised by the absence of any septal perforator branch in the proximal segment of the LAD.

          This case could be useful for pathologists, coronary angiographers, and interventional cardiologists in detecting this infrequent anomaly, thus providing a more accurate estimation of its incidence.

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          The virtual slide(s) for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/vs/3570015858473043

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          Most cited references11

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          Coronary anomalies: incidence, pathophysiology, and clinical relevance.

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            Guidelines for autopsy investigation of sudden cardiac death.

            Although sudden cardiac death is one of the most important mode of death in Western Countries, pathologists and public health physicians have not given this problem the attention it deserves. New methods of preventing potentially fatal arrhythmias have been developed, and the accurate diagnosis of the causes of sudden cardiac death is now of particular importance. Pathologists are responsible for determining the precise cause of sudden death but there is considerable variation in the way in which they approach this increasingly complex task. The Association for European Cardiovascular Pathology developed guidelines, which represent the minimum standard that is required in the routine autopsy practice for the adequate assessment of sudden cardiac death, including not only a protocol for heart examination and histological sampling, but also for toxicology and molecular investigation. Our recommendations apply to university medical centres, regional and district hospitals and all types of forensic medicine institutes. If a uniform method of investigation is adopted throughout the European Union, this will lead to improvements in standards of practice, allow meaningful comparisons between different communities and regions and, most importantly, permit future trends in the patterns of disease causing sudden death to be monitored.
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              Blood supply of the human interventricular septum.

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                Author and article information

                Contributors
                Journal
                Diagn Pathol
                Diagn Pathol
                Diagnostic Pathology
                BioMed Central
                1746-1596
                2013
                28 February 2013
                : 8
                : 41
                Affiliations
                [1 ]Institute of Legal Medicine, Catholic University, Medical School, Rome, Italy
                [2 ]Institute Pathologic Anatomy, Catholic University, Medical School, Rome, Italy
                Article
                1746-1596-8-41
                10.1186/1746-1596-8-41
                3599840
                23448407
                810f7339-c0c1-4231-8b3c-5b2d8b006ad4
                Copyright ©2013 De-Giorgio et al; licensee BioMed Central Ltd.

                This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

                History
                : 12 November 2012
                : 23 January 2013
                Categories
                Case Report

                Pathology
                sudden death,agenesia,septal coronary branches,heart,left descending artery
                Pathology
                sudden death, agenesia, septal coronary branches, heart, left descending artery

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