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      AMPK as a metabolic tumor suppressor: control of metabolism and cell growth.

      1 , ,
      Future oncology (London, England)
      Future Medicine Ltd

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          Abstract

          AMPK is an evolutionarily conserved fuel-sensing enzyme that is activated in shortage of energy and suppressed in its surfeit. AMPK activation stimulates fatty acid oxidation, enhances insulin sensitivity, alleviates hyperglycemia and hyperlipidemia, and inhibits proinflammatory changes. Thus, AMPK is a well-received therapeutic target for metabolic syndrome and Type 2 diabetes. Recent studies indicate that AMPK plays a role in linking metabolic syndrome and cancer. AMPK is an essential mediator of the tumor suppressor LKB1 and could be suppressed in cancer cells containing loss-of-function mutations of LKB1 or containing active mutations of B-Raf, or in cancers associated with metabolic syndrome. The activation of AMPK reprograms cellular metabolism and enforces metabolic checkpoints by acting on mTORC1, p53, fatty acid synthase and other molecules for regulating cell growth and metabolism. In keeping with in vitro studies, recent epidemiological studies indicate that the incidence of cancer is reduced in Type 2 diabetes treated with metformin, an AMPK activator. Thus, AMPK is emerging as an interesting metabolic tumor suppressor and a promising target for cancer prevention and therapy.

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          Author and article information

          Journal
          Future Oncol
          Future oncology (London, England)
          Future Medicine Ltd
          1744-8301
          1479-6694
          Mar 2010
          : 6
          : 3
          Affiliations
          [1 ] Department of Biochemistry, Boston University School of Medicine, MA 02118, USA. zluo@bu.edu
          Article
          NIHMS189279
          10.2217/fon.09.174
          2854547
          20222801
          81187a1c-e786-46e9-a7ba-de9bb1c6d47a
          History

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