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      Power failure: why small sample size undermines the reliability of neuroscience.

      Nature reviews. Neuroscience

      Sample Size, Humans, Neurosciences, Probability, Reproducibility of Results

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          Abstract

          A study with low statistical power has a reduced chance of detecting a true effect, but it is less well appreciated that low power also reduces the likelihood that a statistically significant result reflects a true effect. Here, we show that the average statistical power of studies in the neurosciences is very low. The consequences of this include overestimates of effect size and low reproducibility of results. There are also ethical dimensions to this problem, as unreliable research is inefficient and wasteful. Improving reproducibility in neuroscience is a key priority and requires attention to well-established but often ignored methodological principles.

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          Journal
          10.1038/nrn3475
          23571845

          Chemistry

          Sample Size, Humans, Neurosciences, Probability, Reproducibility of Results

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