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Study of the normal and failing isolated human heart: decreased response of failing heart to isoproterenol.

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      Abstract

      We evaluated the effects of isoproterenol in right ventricular papillary muscles derived from normal and failing isolated human hearts. Basal values for the peak force developed, rate of force development (dF/dt), and time to peak tension (TPT) were similar in both groups. Isoproterenol produced a significantly smaller (p less than 0.05) increase in peak force developed and dF/dt in failing papillary muscles. The half equivalent dose (ED50) of isoproterenol was fivefold higher in failing muscle as compared to normal muscle. We conclude that failing cardiac muscle demonstrates decreased responsiveness to beta-receptor mediated stimulation.

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      Journal
      Am. Heart J.
      American heart journal
      0002-8703
      0002-8703
      Sep 1983
      : 106
      : 3
      6308994
      0002-8703(83)90698-1

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