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      Implication of a genetic variant at PICALM in Alzheimer’s disease patients and centenarians.

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          Abstract

          A common polymorphism (rs3851179) in the PICALM (phosphatidylinositol-binding clathrin assembly protein) gene has been recently associated with reduced risk of developing late-onset Alzheimer’s disease (LOAD). We analyzed the genotype and allele distributions of the PICALM polymorphism in 813 Italian subjects, including LOAD patients and centenarians. The segregation of the PICALM rs3851179 showed no statistically significant difference between LOAD cases and controls. The implication of a genetic variant at PICALM is confirmed for the first time, in centenarians, thus suggesting a possible role in longevity.

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          Author and article information

          Journal
          J. Alzheimers Dis.
          Journal of Alzheimer's disease : JAD
          IOS Press
          1875-8908
          1387-2877
          2011
          : 24
          : 3
          Affiliations
          [1 ] Department of Neurological and Psychiatric Sciences, University of Florence and Centro di Ricerca,Trasferimento e Alta Formazione DENOTHE, University of Florence, Viale Morgagni, Firenze, Italy.
          Article
          R8V3G18624267537
          10.3233/JAD-2011-101791
          21297266
          816ef0fb-d785-4a5b-b962-f4d4b69997d7
          History

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