Blog
About

9
views
0
recommends
+1 Recommend
0 collections
    0
    shares
      • Record: found
      • Abstract: found
      • Article: found
      Is Open Access

      “Yellow-dragon Wonderful-seed Formula” for hyperuricemia in gout patients with dampness-heat pouring downward pattern: a pilot randomized controlled trial

      Read this article at

      Bookmark
          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          Background

          In Traditional Chinese Medicine (TCM) theories, the typical clinical manifestations of gout are attributed to the “dampness-heat pouring downward.” Therefore, TCM practitioners always consider prescribing the formulae which are believed to clear heat and drain dampness for the management of gout. This clinical trial aims: (1) to determine the hypouricemic effect of “Yellow-dragon Wonderful-seed Formula” (YWF) decoction in gout patients with dampness-heat pouring downward pattern and (2) to determine if gypsum could provide additional significant benefits to YWF.

          Methods

          A total of 72 hyperuricemic individuals with gout and dampness-heat pouring downward pattern were included with 62 of them completing the trial. Participants were randomly assigned to the YWF group, the YWF + gypsum group, or the allopurinol group. YWF and YWF + gypsum decoctions were orally administered for four weeks. Allopurinol was also orally administered for four weeks as the active control. Serum uric acid (sUA) level was the primary outcome measure. Urine urate level, scores on the SF-36 scale, erythrocyte sedimentation rate (ESR), X ray film, and C reactive protein (CRP) level were the secondary outcome measures.

          Results

          Compared with the values at week 0, YWF and YWF + gypsum did not significantly decrease the sUA level at each weekend reading. YWF, YWF + gypsum, and allopurinol decreased the urine urate levels and there were significant differences between the YWF group and the YWF + gypsum group. All the changes in the eight structures of SF-36 during the intervention period were not significantly different among the three groups and there was no significant difference in the CRP level among the three groups at each weekend reading.

          Conclusions

          YWM, which modified on the basis of Two Wonderful Herbs Powder ( 2WHP), does not show significant hypouricemic effect. There is a possibility that Gypsum Fibrosum may provide additional effects to YWF in decreasing the urine urate levels but cannot add benefits to YWF in other outcome measures.

          Trial registration

          Chinese Clinical Trial Registry, ChiCTR-TRC-12001933. Registered on 10 February 2012.

          Electronic supplementary material

          The online version of this article (10.1186/s13063-018-2917-8) contains supplementary material, which is available to authorized users.

          Related collections

          Most cited references 26

          • Record: found
          • Abstract: found
          • Article: found
          Is Open Access

          Prevalence of Hyperuricemia and Gout in Mainland China from 2000 to 2014: A Systematic Review and Meta-Analysis

          We systematically identified the prevalence of hyperuricemia and gout in mainland China and provided informative data that can be used to create appropriate local public health policies. Relevant articles from 2000 to 2014 were identified by searching 5 electronic databases: PubMed, Google Scholar, Chinese Wanfang, CNKI, and Chongqing VIP. All of the calculations were performed using the Stata 11.0 and SPSS 20.0 software. The eligible articles (n = 36; 3 in English and 33 in Chinese) included 44 studies (38 regarding hyperuricemia and 6 regarding gout). The pooled prevalence of hyperuricemia and gout was 13.3% (95% CI: 11.9%, 14.6%) and 1.1% (95% CI: 0.7%, 1.5%), respectively. Although publication bias was observed, the results did not change after a trim and fill test, indicating that that impact of this bias was likely insignificant. The prevalence of hyperuricemia and gout was high in mainland China. The subgroup analysis suggested that the geographical region, whether the residents dwell in urban or rural and coastal or inland areas, the economic level, and sex may be associated with prevalence.
            Bookmark
            • Record: found
            • Abstract: found
            • Article: not found

            Epidemiology of gout.

            Gout is the most prevalent inflammatory arthritis in men. The findings of several epidemiologic studies from a diverse range of countries suggest that the prevalence of gout has risen over the past few decades. Although incidence data are scarce, data from the United States suggests that the incidence of gout is also rising. Evidence from prospective epidemiologic studies has confirmed dietary factors (animal purines, alcohol, and fructose), obesity, the metabolic syndrome, hypertension, diuretic use, and chronic kidney disease as clinically relevant risk factors for hyperuricemia and gout. Low-fat dairy products, coffee, and vitamin C seem to have a protective effect.
              Bookmark
              • Record: found
              • Abstract: found
              • Article: not found

              A network pharmacology approach to determine active ingredients and rationality of herb combinations of Modified-Simiaowan for treatment of gout.

              Modified Simiaowan (MSW) is a traditional Chinese medicine (TCM) formula and is widely used as a clinically medication formula for its efficiency in treating gouty diseases.To predict the active ingredients in MSW and uncover the rationality of herb combinations of MSW.
                Bookmark

                Author and article information

                Contributors
                604016781@qq.com
                848733208@qq.com
                592889123@qq.com
                546442781@qq.com
                kytbh@126.com
                641324933@qq.com
                346873785@qq.com
                tuxiang2005@163.com
                jjordan727@yahoo.com
                zhongsen6606@163.com
                Journal
                Trials
                Trials
                Trials
                BioMed Central (London )
                1745-6215
                11 October 2018
                11 October 2018
                2018
                : 19
                Affiliations
                [1 ]ISNI 0000 0001 0376 205X, GRID grid.411304.3, Basic Medical College of Chengdu University of Traditional Chinese Medicine, ; Chengdu, 611137 Sichuan Province China
                [2 ]ISNI 0000 0004 1808 0950, GRID grid.410646.1, Department of Gerontology, , Sichuan Academy of Medical Sciences & Sichuan Provincial People’s Hospital, ; Chengdu, 610072 Sichuan Province China
                [3 ]Department of Internal Medicine, Traditional Chinese Medicine Hospital of Fushun County, Fushun, 643200 Sichuan Province China
                [4 ]Department of Internal Medicine, Traditional Chinese Medicine Hospital of Pidu District, Chengdu, 611730 Sichuan Province China
                [5 ]Department of Internal Medicine, Traditional Chinese Medicine Hospital of Kaizhou District, Chongqing City, 405400 China
                [6 ]ISNI 0000 0001 0376 205X, GRID grid.411304.3, College of Clinical Medicine, , Chengdu University of Traditional Chinese Medicine, ; Chengdu, 610075 Sichuan Province China
                [7 ]GRID grid.415440.0, National Traditional Chinese Medicine Clinical Research Base for Diabetes Mellitus/Teaching Hospital of Chengdu University of Traditional Chinese Medicine, ; Chengdu, 610072 Sichuan Province China
                [8 ]ISNI 0000 0001 0376 205X, GRID grid.411304.3, Administration Committee of Affiliated Hospitals of Chengdu University of Traditional Chinese Medicine, ; Chengdu, 611137 Sichuan Province China
                Article
                2917
                10.1186/s13063-018-2917-8
                6186073
                30314508
                © The Author(s). 2018

                Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License ( http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver ( http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

                Funding
                Funded by: Physician Investigator Foundation of National TCM Clinical Research Base for Diabetes Mellitus
                Award ID: CSZYJ2011010
                Award Recipient :
                Categories
                Research
                Custom metadata
                © The Author(s) 2018

                Comments

                Comment on this article