Efficacy of Nintedanib in Idiopathic Pulmonary Fibrosis across Prespecified Subgroups in INPULSIS.

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Abstract

In the two replicate, placebo-controlled, 52-week, phase III INPULSIS trials, nintedanib 150 mg twice daily significantly reduced the annual rate of decline in FVC, the primary endpoint, in subjects with idiopathic pulmonary fibrosis (IPF). It is unknown if this effect was uniform across all subjects treated with nintedanib.

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Journal

Journal ID (iso-abbrev): Am. J. Respir. Crit. Care Med.

Title: American journal of respiratory and critical care medicine

ISSN (Electronic): 1535-4970

ISSN (Print): 1073-449X

Publication date (Electronic): Jan 15 2016

Volume: 193

Issue: 2

Affiliations

[1 ] 1 Ruhrlandklinik, University Hospital, University of Duisburg-Essen, Essen, Germany.

[2 ] 2 Clinical Research Center, National Hospital Organization Kinki-Chuo Chest Medical Center, Osaka, Japan.

[3 ] 3 National Institute for Health Research Southampton Respiratory Biomedical Research Unit and Clinical and Experimental Sciences, University of Southampton, Southampton, United Kingdom.

[4 ] 4 Division of Pulmonary and Critical Care Medicine, Department of Medicine, University of California San Francisco, San Francisco, California.

[5 ] 5 Boehringer Ingelheim France S.A.S., Reims, France.

[6 ] 6 Boehringer Ingelheim Pharma GmbH & Co. KG, Ingelheim am Rhein, Germany; and.

[7 ] 7 Department of Pulmonary Medicine and Oncology, Graduate School of Medicine, Nippon Medical School, Tokyo, Japan.

Article

DOI: 10.1164/rccm.201503-0562OC

PubMed ID: 26393389

SO-VID: 8175cdd6-f22f-46e7-b38d-369db4b2f920

History

Keywords: disease progression,forced vital capacity,quality of life

Data availability:

Keywords: disease progression, forced vital capacity, quality of life

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