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      Acromegaly and Hyperthyroidism Associated with McCune-Albright Syndrome

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          Abstract

          A 36-year-old man is described having McCune-Albright syndrome, acromegaly likely due to somatotroph hyperplasia and hyperthyroidism due to adenomatous goiter. Sexual precocity was not noted. The sella was narrow in size and no mass was seen. The decline of elevated GH by hyperglycemia and increase by GHRH-44(NH<sub>2</sub>) may support somatotroph hyperplasia, but plasma GHRH-44(NH<sub>2</sub>) levels were not elevated. A mass in the right lobe and enlargement of the left lobe of the thyroid were noted. Thyroid hormone levels in serum and thyroidal radioiodine uptake values were elevated, while TSH measurements in serum were low. The radioiodine scan showed a cold nodule in the right lobe and a hot area in the left of the thyroid. Thyroidal radioiodine was not suppressed following T<sub>3</sub> given orally. These findings are compatible with functioning glands autonomously as the mechanism for the endocrinopathies associated with the McCune-Albright syndrome.

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          Author and article information

          Journal
          HRE
          Horm Res Paediatr
          10.1159/issn.1663-2818
          Hormone Research in Paediatrics
          S. Karger AG
          1663-2818
          1663-2826
          1988
          1988
          02 December 2008
          : 30
          : 1
          : 26-27
          Affiliations
          aStudent Health Center, Mie University, and bThird Department of Internal Medicine, Mie University School of Medicine, Tsu, Japan
          Article
          181021 Horm Res 1988;30:26–27
          10.1159/000181021
          3220461
          © 1988 S. Karger AG, Basel

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          Pages: 2
          Categories
          Original Paper

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