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Increased activation of nuclear factor-kappa B (NF-κB) in isolated peritoneal macrophages of patients with endometriosis
Jean-Christophe Lousse ,
Anne Van Langendonckt ,
Reinaldo González-Ramos ,
Sylvie Defrère ,
Emmanuelle Renkin ,
Jacques Donnez
July 2008
July 2008
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Abstract
Endometriosis is characterized by pelvic inflammation that shows an increased number
of activated peritoneal macrophages and their secreted products such as cytokines,
growth factors, and angiogenic factors. Our results show that activation of nuclear
factor-kappa B (NF-kappaB), a pro-inflammatory transcription factor, is statistically
significantly increased in peritoneal macrophages from patients with endometriosis
when compared with controls.