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Dietary flavonoid genistein induces Nrf2 and phase II detoxification gene expression via ERKs and PKC pathways and protects against oxidative stress in Caco-2 cells.
Xiaohan Zhai
1 ,
Musen Lin ,
Feng Zhang ,
Yan Hu ,
Xiaomei Xu ,
Yubing Li ,
Kexin Liu ,
Xiaochi Ma ,
Xiaofeng Tian ,
Jihong Yao
Feb 2013
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Abstract
Flavonoids have well-known antioxidant, anti-inflammatory, and anti-cancer activities. Isoflavone genistein is considered a potent antioxidant agent against oxidative stress. Although several mechanisms have been proposed, a clear antioxidant mechanism of genistein is still remained to be answered.