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Abstract

The Hedgehog signal transducer Smoothened is structurally similar to G protein-coupled receptors. Now there is direct evidence that Smoothened relies on heterotrimeric G proteins in order to transduce the Hedgehog signal.

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PubMed ID:: 19211052

DOI:: 10.1016/j.cub.2008.12.010

ScienceOpen disciplines: Chemistry

Keywords: Drosophila Proteins,genetics,metabolism,Hedgehog Proteins,Models, Biological,Receptors, G-Protein-Coupled,Signal Transduction,physiology

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ScienceOpen disciplines: Chemistry

Keywords: Drosophila Proteins, genetics, metabolism, Hedgehog Proteins, Models, Biological, Receptors, G-Protein-Coupled, Signal Transduction, physiology

Hedgehog signaling: is Smo a G protein-coupled receptor?

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Abstract

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Journal of Circulating Biomarkers

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