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      Serum Renin Activity in Human Renal Homotransplantation

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      Nephron

      S. Karger AG

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          Abstract

          Serial determinations of serum renin activity (RA) have been made in 19 patients recipient of 21 allografts. Five patients received kidneys from 4 related and from 1 unrelated living donors; 13 patients received allografts from 15 adult cadavers, and 1 from an anencephalic newborn. During the first post transplant month observations were made in 18 recipients. RA was found increased transiently in 7 and persistently in 10 recipients. The increase in RA was associated with acute tubular necrosis, 5; occlusive vascular lesions of the graft artery or its branches and infarction of the graft, 4; cortical necrosis, 2; and acute rejection, 3. In 2 recipients no apparent cause for the rise in RA could be found, and in 1 the increase was probably related to diuretic therapy. During the late post transplant period, from 2 months to 2 years and 8 months, observations were made in 10 recipients. RA remained increased in 2 recipients with occlusive vascular lesions and rejection of the allograft, respectively. In 6 other recipients RA increased in association with rejection, 4; development of graft artery stenosis, 1; and diuretic therapy, 1. In 2 recipients with uneventful course RA remained normal. There was no statistically significant correlation between changes in RA and endogenous creatinine clearance, or body weight. However, there was a significant negative correlation between RA and sodium excretion, and a small positive correlation between RA and diastolic blood pressure.

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          Author and article information

          Journal
          NEF
          Nephron
          10.1159/issn.1660-8151
          Nephron
          S. Karger AG
          1660-8151
          2235-3186
          1971
          1971
          26 November 2008
          : 8
          : 3
          : 289-302
          Affiliations
          Department of Medicine, Northwestern University Medical School and Passavant Memorial Hospital, Chicago, Ill.
          Article
          179930 Nephron 1971;8:289–302
          10.1159/000179930
          4949581
          © 1971 S. Karger AG, Basel

          Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

          Page count
          Pages: 14
          Categories
          Paper

          Cardiovascular Medicine, Nephrology

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