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      Clonal evolution in cancer.

      1 ,
      Nature
      Springer Science and Business Media LLC

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          Abstract

          Cancers evolve by a reiterative process of clonal expansion, genetic diversification and clonal selection within the adaptive landscapes of tissue ecosystems. The dynamics are complex, with highly variable patterns of genetic diversity and resulting clonal architecture. Therapeutic intervention may destroy cancer clones and erode their habitats, but it can also inadvertently provide a potent selective pressure for the expansion of resistant variants. The inherently Darwinian character of cancer is the primary reason for this therapeutic failure, but it may also hold the key to more effective control.

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          Author and article information

          Journal
          Nature
          Nature
          Springer Science and Business Media LLC
          1476-4687
          0028-0836
          Jan 18 2012
          : 481
          : 7381
          Affiliations
          [1 ] Division of Molecular Pathology, The Institute of Cancer Research, Brookes Lawley Building, 15 Cotswold Road, Sutton, Surrey SM2 5NG, UK. mel.greaves@icr.ac.uk
          Article
          nature10762 NIHMS377748
          10.1038/nature10762
          3367003
          22258609
          81bab0d7-fcc5-408b-b116-addfa782c659
          History

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