Allergy-related outcomes and sleep-related disorders in adults: a cross-sectional study based on NHANES 2005–2006

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Abstract

Background

Epidemiological evidence between the sleep disorders and allergy-related outcomes is limited.

Objectives

The purpose of the present study was to estimate the relationship between sleep disorders and allergy-related outcomes in adults.

Methods

We built logistic regression models to examine the associations between sleep disorders and allergy-related outcomes in adult participants using the 2005–2006 NHANES database. Allergy-related outcomes included sIgE levels, asthma, hay fever, sneezing, wheezing, and eczema. Sleep disorders included sleep latency, sleep length, sleep problems, OSA symptoms, and daytime sleepiness. A t-test was used for between-group comparisons.

Results

Participants with OSA symptoms had 2.72 × higher odds of experiencing hay fever and 1.54 × higher odds of having eczema compared to Non-OSA symptoms participants. Participants with insufficient sleep (≤ 6 h/night) had 1.27 × higher odds of developing allergic sensitisation compared to participants with adequate sleep (7–8 h/night). Sneezing was positively associated with sleep problems (OR: 1.706; 95% CI 1.386, 2.099), OSA symptoms (OR: 1.297; 95% CI 1.049, 1.605), and daytime sleepiness (OR: 1.569; 95% CI 1.205, 2.04).

Conclusion

Our findings suggest a positive association between allergy-related outcomes and sleep disorders. In particular, OSA symptoms, daytime sleepiness, and sleep problems are strongly associated with allergic conditions.

Graphical Abstract

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Most cited references 39

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Prospective study of the association between sleep-disordered breathing and hypertension.

Paul E Peppard, Terry Young, Mari Palta … (2000)

Sleep-disordered breathing is prevalent in the general population and has been linked to chronically elevated blood pressure in cross-sectional epidemiologic studies. We performed a prospective, population-based study of the association between objectively measured sleep-disordered breathing and hypertension (defined as a laboratory-measured blood pressure of at least 140/90 mm Hg or the use of antihypertensive medications). We analyzed data on sleep-disordered breathing, blood pressure, habitus, and health history at base line and after four years of follow-up in 709 participants of the Wisconsin Sleep Cohort Study (and after eight years of follow-up in the case of 184 of these participants). Participants were assessed overnight by 18-channel polysomnography for sleep-disordered breathing, as defined by the apnea-hypopnea index (the number of episodes of apnea and hypopnea per hour of sleep). The odds ratios for the presence of hypertension at the four-year follow-up study according to the apnea-hypopnea index at base line were estimated after adjustment for base-line hypertension status, body-mass index, neck and waist circumference, age, sex, and weekly use of alcohol and cigarettes. Relative to the reference category of an apnea-hypopnea index of 0 events per hour at base line, the odds ratios for the presence of hypertension at follow-up were 1.42 (95 percent confidence interval, 1.13 to 1.78) with an apnea-hypopnea index of 0.1 to 4.9 events per hour at base line as compared with none, 2.03 (95 percent confidence interval, 1.29 to 3.17) with an apnea-hypopnea index of 5.0 to 14.9 events per hour, and 2.89 (95 percent confidence interval, 1.46 to 5.64) with an apnea-hypopnea index of 15.0 or more events per hour. We found a dose-response association between sleep-disordered breathing at base line and the presence of hypertension four years later that was independent of known confounding factors. The findings suggest that sleep-disordered breathing is likely to be a risk factor for hypertension and consequent cardiovascular morbidity in the general population.

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Obstructive sleep apnea is a common disorder in the population-a review on the epidemiology of sleep apnea.

Karl Franklin, Eva Hellstrom-Lindberg (2015)

The prevalence of obstructive sleep apnea (OSA) defined at an apnea-hypopnea index (AHI) ≥5 was a mean of 22% (range, 9-37%) in men and 17% (range, 4-50%) in women in eleven published epidemiological studies published between 1993 and 2013. OSA with excessive daytime sleepiness occurred in 6% (range, 3-18%) of men and in 4% (range, 1-17%) of women. The prevalence increased with time and OSA was reported in 37% of men and in 50% of women in studies from 2008 and 2013 respectively. OSA is more prevalent in men than in women and increases with age and obesity. Smoking and alcohol consumption are also suggested as risk factors, but the results are conflicting. Excessive daytime sleepiness is suggested as the most important symptom of OSA, but only a fraction of subjects with AHI >5 report daytime sleepiness and one study did not find any relationship between daytime sleepiness and sleep apnea in women. Stroke and hypertension and coronary artery disease are associated with sleep apnea. Cross-sectional studies indicate an association between OSA and diabetes mellitus. Patients younger than 70 years run an increased risk of early death if they suffer from OSA. It is concluded that OSA is highly prevalent in the population. It is related to age and obesity. Only a part of subjects with OSA in the population have symptoms of daytime sleepiness. The prevalence of OSA has increased in epidemiological studies over time. Differences and the increase in prevalence of sleep apnea are probably due to different diagnostic equipment, definitions, study design and characteristics of included subjects including effects of the obesity epidemic. Cardiovascular disease, especially stroke is related to OSA, and subjects under the age of 70 run an increased risk of early death if they suffer from OSA.

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Is Open Access

World allergy organization anaphylaxis guidance 2020

Victoria Cardona, Ignacio J. Ansotegui, Motohiro Ebisawa … (2020)

Anaphylaxis is the most severe clinical presentation of acute systemic allergic reactions. The occurrence of anaphylaxis has increased in recent years, and subsequently, there is a need to continue disseminating knowledge on the diagnosis and management, so every healthcare professional is prepared to deal with such emergencies. The rationale of this updated position document is the need to keep guidance aligned with the current state of the art of knowledge in anaphylaxis management. The World Allergy Organization (WAO) anaphylaxis guidelines were published in 2011, and the current guidance adopts their major indications, incorporating some novel changes. Intramuscular epinephrine (adrenaline) continues to be the first-line treatment for anaphylaxis. Nevertheless, its use remains suboptimal. After an anaphylaxis occurrence, patients should be referred to a specialist to assess the potential cause and to be educated on prevention of recurrences and self-management. The limited availability of epinephrine auto-injectors remains a major problem in many countries, as well as their affordability for some patients.

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Author and article information

Contributors

Ze-Zhang Tao: taozezhang696@163.com

Journal

Journal ID (nlm-ta): Allergy Asthma Clin Immunol

Journal ID (iso-abbrev): Allergy Asthma Clin Immunol

Title: Allergy, Asthma, and Clinical Immunology : Official Journal of the Canadian Society of Allergy and Clinical Immunology

Publisher: BioMed Central (London )

ISSN (Print): 1710-1484

ISSN (Electronic): 1710-1492

Publication date (Electronic): 22 March 2022

Publication date PMC-release: 22 March 2022

Publication date Collection: 2022

Volume: 18

Electronic Location Identifier: 27

Affiliations

[1 ]GRID grid.412632.0, ISNI 0000 0004 1758 2270, Department of Otolaryngology, Head and Neck Surgery, , Renmin Hospital of Wuhan University, ; 238 Jie-Fang Road, Wuhan, 430060 Hubei People’s Republic of China

[2 ]GRID grid.412632.0, ISNI 0000 0004 1758 2270, Institute of Otolaryngology, Head and Neck Surgery, , Renmin Hospital of Wuhan University, ; Wuhan, People’s Republic of China

Article

Publisher ID: 669

DOI: 10.1186/s13223-022-00669-z

PMC ID: 8941730

PubMed ID: 35317862

SO-VID: 81c154df-7179-4272-9f2c-c172302d149d

License:

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver ( http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

History

Date received : 9 November 2021

Date accepted : 10 March 2022

Funding

Funded by: FundRef http://dx.doi.org/10.13039/501100001809, National Natural Science Foundation of China;

Award ID: 81870705

Award ID: 81970860

Award Recipient : Ze-Zhang Tao

Custom metadata

ScienceOpen disciplines: Immunology

Keywords: allergy,sleep disorders,epidemiology,clinical study

Data availability:

ScienceOpen disciplines: Immunology

Keywords: allergy, sleep disorders, epidemiology, clinical study

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Allergy-related outcomes and sleep-related disorders in adults: a cross-sectional study based on NHANES 2005–2006

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Abstract

Background

Objectives

Methods

Results

Conclusion

Graphical Abstract

Related collections

Gamma Delta T cells

Most cited references 39

Prospective study of the association between sleep-disordered breathing and hypertension.

Obstructive sleep apnea is a common disorder in the population-a review on the epidemiology of sleep apnea.

World allergy organization anaphylaxis guidance 2020

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Cited by 8

Most referenced authors 418