6
views
0
recommends
+1 Recommend
0 collections
    0
    shares
      • Record: found
      • Abstract: found
      • Article: not found

      Interictal serum S-100B protein levels in intractable epilepsy: a case-control study.

      Read this article at

      ScienceOpenPublisherPubMed
      Bookmark
          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          Epilepsy is the most common neurologic disorder of childhood. In approximately 6-14% of all patients with epilepsy, complete seizure control is difficult to achieve with current antiepileptic treatments. Several current studies have shown in both animals and people that the lengthening of epileptic seizures and frequent recurrence increases the likelihood of neuronal damage. S-100B protein is the most analyzed brain derived peripheral biochemical marker in brain damage. This study aimed to evaluate interictal serum S-100B protein levels in children diagnosed with intractable epilepsy. A group of 32 patients with intractable epilepsy and 25 healthy controls were recruited. Serum S-100B protein levels were measured using a commercially available electrochemiluminescence immunoassay (ECLIA kit, as supplied and according to the manufacturer's standards. The serum S-100B protein levels of the patient group in the study were found to be 0.094±0.011 μm/L, and 0.083±0.014 μm/L in the age-matched control group. The difference between the groups was determined to be statistically significant (P=0.004). In conclusions, it can be said that as the serum S-100B protein levels of the patients with focal epilepsy were high compared to those of the control group, this can be reliable peripheral biomarker for neuronal damage in patients with focal intractable epilepsy.

          Related collections

          Author and article information

          Journal
          Neurosci. Lett.
          Neuroscience letters
          Elsevier BV
          1872-7972
          0304-3940
          Jan 13 2014
          : 558
          Affiliations
          [1 ] Department of Pediatric Neurology, Harran University School of Medicine, Sanliurfa, Turkey. Electronic address: m.calik80@hotmail.com.
          [2 ] Department of Pediatrics, Harran University School of Medicine, Sanliurfa, Turkey.
          [3 ] Department of Child and Adolescent Psychiatry, Harran University School of Medicine, Sanliurfa, Turkey.
          [4 ] Department of Clinical Fizyology, Harran University School of Medicine, Sanliurfa, Turkey.
          [5 ] Department of Biochemistry and Clinical Biochemistry, Harran University School of Medicine, Sanliurfa, Turkey.
          [6 ] Department of Pediatric Neurology, BezmialemVakif University, Faculty of Medicine, Istanbul, Turkey.
          Article
          S0304-3940(13)00944-0
          10.1016/j.neulet.2013.10.040
          24211222
          81cba48a-a1be-4b38-b3ea-e9cd91133195
          History

          S-100B,Focal intractable epilepsy,Childhood,Biomarker
          S-100B, Focal intractable epilepsy, Childhood, Biomarker

          Comments

          Comment on this article