In 12 patients with coronary heart disease, the end-systolic and end-diastolic left-ventricular volumes were measured employing three-dimensional echocardiography. Cardiac output (CO<sub>e</sub>) and stroke volume (SV<sub>e</sub>) were calculated and correlation with simultaneous thermal dilution measurements (CO<sub>th</sub>, SV<sub>th</sub>) was performed. In 9 subjects the variability between the mean heart rate and the heart rate at any given time was found to be < 10% (observer 1: SV<sub>e</sub> vs. SV<sub>th</sub> r = 0.78, p < 0.01, CO<sub>e</sub> vs. CO<sub>th</sub> r = 0.86, p < 0.01 and in 9 cases with steady heart rate SV<sub>e</sub> vs. SV<sub>th</sub> r = 0.95, p < 0.01; observer 2: SV<sub>e</sub> vs. SV<sub>th</sub> r = 0.78, p < 0.01, CO<sub>e</sub> vs. CO<sub>th</sub> r = 0.77, p < 0.01 and in 9 cases with steady heart rate SV<sub>e</sub> vs. SV<sub>th</sub> r = 0.93, p < 0.01). Using the new bedside approach three-dimensional imaging and volumetry becomes possible by means of one examination.