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      MRI of Blood Volume and Cellular Uptake of Superparamagnetic Iron in an Animal Model of Choroidal Melanoma


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          Functional magnetic resonance imaging (MRI), using monocrystalline iron oxide nanoparticles (MION) as a new intravascular contrast agent, was adapted for a rabbit model of pigmented choroidal melanoma. Three-dimensionally spoiled gradient recalled sequences were used for the quantitative assessment of blood volume and cellular uptake. In all ocular tissues studied, MION reduced the T<sub>2</sub>-weighted signal intensity within 0.5 h and at 24 h (both p < 0.05) after the injection. In individual tumors, MION reduced the T<sub>2</sub>-weighted signal intensity by 46–78% within 0.5 h and by 24–48% at 24 h. In addition, MION increased the T<sub>1</sub>-weighted signal intensity in all tissues. T<sub>2</sub> yielded a higher sensitivity than T<sub>1</sub>-weighted images. Functional MRI with MION is a noninvasive technique with regard to the eye, permitting measurement of blood volume and cellular uptake of the contrast agent. Further study is necessary to determine the feasibility of this technique for the tumor diagnosis and evaluation of tumor viability following treatments.

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          Author and article information

          Ophthalmic Res
          Ophthalmic Research
          S. Karger AG
          August 2002
          16 September 2002
          : 34
          : 4
          : 241-250
          aMassachusetts Eye and Ear Infirmary, Department of Ophthalmology, Harvard Medical School, Boston, Mass., and bMassachusetts General Hospital-Nuclear Magnetic Resonance Center, Harvard Medical School, Charlestown, Mass., USA
          63883 Ophthalmic Res 2002;34:241–250
          © 2002 S. Karger AG, Basel

          Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

          : 30 October 2001
          : 18 February 2002
          Page count
          Figures: 5, Tables: 2, References: 67, Pages: 10
          Original Paper

          Vision sciences,Ophthalmology & Optometry,Pathology
          Blood volume,Pharmacokinetics,Pathology,Diagnostic use,Nuclear magnetic resonance,Ferric compounds,Physiopathology,Melanoma,Choroid neoplasms


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